A transcultural cognitive marker of Alzheimer's Disease

Sergio Della Sala, Irina Kozlova, Andreaa Stamate, Mario A. Parra

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective. Temporary Binding (TB) is sensitive and specific to Alzheimer’s Disease (AD), is not affected by age, repeated testing or level of education. Hence, TB is useful to assess patients with very different socio-cultural backgrounds. However, the current computerized version of the test is not suitable for use in clinical settings. The aim of this study was to investigate whether a clinically friendly version of the TB task results in overlapping outcomes compared to the computerised version.Methods. A newly devised Flash-card version of the TB assesses temporary visual binding for arrays of stimuli such as shapes (polygons), colours, or combinations of shapes and colours. In Experiment 1 this version was compared with the laboratory computerised version. In Experiment 2, 33 AD patients and 33 matched controls, recruited from various geriatric centres in Romania, were assessed with the new TB test and with Free and Cued Selective Reminding test.Results. The results with the Flash-card version of the TB test were comparable to those obtained with the computerised version. TB was not affected by age but it was impaired by AD. The sensitivity and specificity of the new TB test were found to be greater than those achieved by a Selective Reminding test.Conclusions. TB deficits may be conceived as a fundamental marker of AD. The Flash-card version is suitable for clinical use also in primary care facilities and in intervention trials, requires minimal training for administration and scoring, is quick to administer, non-invasive, inexpensive and facilitates cross-cultural studies.
LanguageEnglish
Pages849-856
Number of pages8
JournalInternational Journal of Geriatric Psychiatry
Volume33
Issue number6
Early online date2 Nov 2016
DOIs
Publication statusPublished - 30 Jun 2018

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Alzheimer Disease
Color
Romania
Geriatrics
Primary Health Care
Education
Sensitivity and Specificity

Keywords

  • alzheimers disease
  • temporary binding
  • flash-cards
  • cognitive marker
  • selective reminding

Cite this

Della Sala, Sergio ; Kozlova, Irina ; Stamate, Andreaa ; Parra, Mario A. / A transcultural cognitive marker of Alzheimer's Disease. In: International Journal of Geriatric Psychiatry. 2018 ; Vol. 33, No. 6. pp. 849-856.
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A transcultural cognitive marker of Alzheimer's Disease. / Della Sala, Sergio; Kozlova, Irina; Stamate, Andreaa; Parra, Mario A.

In: International Journal of Geriatric Psychiatry, Vol. 33, No. 6, 30.06.2018, p. 849-856.

Research output: Contribution to journalArticle

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N2 - Objective. Temporary Binding (TB) is sensitive and specific to Alzheimer’s Disease (AD), is not affected by age, repeated testing or level of education. Hence, TB is useful to assess patients with very different socio-cultural backgrounds. However, the current computerized version of the test is not suitable for use in clinical settings. The aim of this study was to investigate whether a clinically friendly version of the TB task results in overlapping outcomes compared to the computerised version.Methods. A newly devised Flash-card version of the TB assesses temporary visual binding for arrays of stimuli such as shapes (polygons), colours, or combinations of shapes and colours. In Experiment 1 this version was compared with the laboratory computerised version. In Experiment 2, 33 AD patients and 33 matched controls, recruited from various geriatric centres in Romania, were assessed with the new TB test and with Free and Cued Selective Reminding test.Results. The results with the Flash-card version of the TB test were comparable to those obtained with the computerised version. TB was not affected by age but it was impaired by AD. The sensitivity and specificity of the new TB test were found to be greater than those achieved by a Selective Reminding test.Conclusions. TB deficits may be conceived as a fundamental marker of AD. The Flash-card version is suitable for clinical use also in primary care facilities and in intervention trials, requires minimal training for administration and scoring, is quick to administer, non-invasive, inexpensive and facilitates cross-cultural studies.

AB - Objective. Temporary Binding (TB) is sensitive and specific to Alzheimer’s Disease (AD), is not affected by age, repeated testing or level of education. Hence, TB is useful to assess patients with very different socio-cultural backgrounds. However, the current computerized version of the test is not suitable for use in clinical settings. The aim of this study was to investigate whether a clinically friendly version of the TB task results in overlapping outcomes compared to the computerised version.Methods. A newly devised Flash-card version of the TB assesses temporary visual binding for arrays of stimuli such as shapes (polygons), colours, or combinations of shapes and colours. In Experiment 1 this version was compared with the laboratory computerised version. In Experiment 2, 33 AD patients and 33 matched controls, recruited from various geriatric centres in Romania, were assessed with the new TB test and with Free and Cued Selective Reminding test.Results. The results with the Flash-card version of the TB test were comparable to those obtained with the computerised version. TB was not affected by age but it was impaired by AD. The sensitivity and specificity of the new TB test were found to be greater than those achieved by a Selective Reminding test.Conclusions. TB deficits may be conceived as a fundamental marker of AD. The Flash-card version is suitable for clinical use also in primary care facilities and in intervention trials, requires minimal training for administration and scoring, is quick to administer, non-invasive, inexpensive and facilitates cross-cultural studies.

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