A traceless solid-phase synthesis of pteridines

C.L. Gibson, S. La Rosa, C.J. Suckling

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The linking of pyrimidines to polystyrene supports via either a 2- or 4-thioether provides access to pteridines through solid-phase synthesis. Oxidative cleavage (dimethyldioxirane) followed by nucleophilic substitution by amines, azide, or water completes a traceless synthesis of pteridines.
Original languageEnglish
Pages (from-to)1267-1270
Number of pages3
JournalTetrahedron Letters
Volume44
Issue number6
DOIs
Publication statusPublished - 3 Feb 2003

Keywords

  • pyrimidines
  • polystyrene
  • oxidative cleavage

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