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Abstract
Towards the synthesis of the novel natural product Agariblazeispirol C, (5aR*,11bR*)-9-methoxy-3,8,11b-trimethyl-5,6,7,11b-tetrahydro-1H-pentaleno[1,6a-a]naphthalen-4(2H)-one, C20H24O2, has been prepared at a key stage of the preparative programme. The structure shows the desired stereochemical outcome of the central cyclization protocol, viz. a syn-relationship between the aliphatic methyl group on the 11b-position and the methylene group on the 5a-position [C-C-C-C = -34.57 (18)degrees].
Original language | English |
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Pages (from-to) | 473-474 |
Number of pages | 2 |
Journal | Acta Crystallographica Section C: Crystal Structure Communications |
Volume | 66 |
DOIs | |
Publication status | Published - Sep 2010 |
Keywords
- alpha-carbonyl radicals
- formal total-synthesis
- beta-cedrene
- cyclization
- cedrone
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Projects
- 1 Finished