A systematic approach in analyzing sustained oscillations in an NF-kB signal transduction pathway system

B. Lu, H. Yue, The National Natural Science Foundation of China (30770560) (Funder)

Research output: Contribution to journalArticle

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Abstract

Oscillation phenomenon is very common in biological systems. It is crucial to study oscillatory behaviors to understand gene regulation functions. Model-based analysis in combination with experimental study provides a new and systematic way to investigate biological oscillations. The nuclear factor-kB (NF-kB) signaling is an important signaling pathway that is involved in a variety of cellular processes including immune response, inflammation, and apoptosis. Recent studies revealed damped oscillations of NF-kB activity both experimentally and computationally, etc. In this work, based on a differential equation model, bifurcation analysis was used to examine whether it was possible for this system to produce sustained oscillations (limit cycle oscillations) rather than damped oscillations. Both one- and two-parameter bifurcation analyses have been performed and it was found that certain conditions could possibly result in sustained oscillations of nuclear NF-kB activity. The parameter regimes corresponding to such oscillations were calculated with this method.
Original languageEnglish
Pages (from-to)406-420
Number of pages14
JournalActa Biophysica Sinica
Volume26
Issue number5
Publication statusPublished - May 2010

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oscillations
gene expression
apoptosis
differential equations
cycles

Keywords

  • sustained oscillations
  • signal transduction
  • pathway system

Cite this

Lu, B., Yue, H., & The National Natural Science Foundation of China (30770560) (Funder) (2010). A systematic approach in analyzing sustained oscillations in an NF-kB signal transduction pathway system. Acta Biophysica Sinica, 26(5), 406-420.
Lu, B. ; Yue, H. ; The National Natural Science Foundation of China (30770560) (Funder). / A systematic approach in analyzing sustained oscillations in an NF-kB signal transduction pathway system. In: Acta Biophysica Sinica. 2010 ; Vol. 26, No. 5. pp. 406-420.
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Lu, B, Yue, H & The National Natural Science Foundation of China (30770560) (Funder) 2010, 'A systematic approach in analyzing sustained oscillations in an NF-kB signal transduction pathway system', Acta Biophysica Sinica, vol. 26, no. 5, pp. 406-420.

A systematic approach in analyzing sustained oscillations in an NF-kB signal transduction pathway system. / Lu, B.; Yue, H.; The National Natural Science Foundation of China (30770560) (Funder).

In: Acta Biophysica Sinica, Vol. 26, No. 5, 05.2010, p. 406-420.

Research output: Contribution to journalArticle

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AB - Oscillation phenomenon is very common in biological systems. It is crucial to study oscillatory behaviors to understand gene regulation functions. Model-based analysis in combination with experimental study provides a new and systematic way to investigate biological oscillations. The nuclear factor-kB (NF-kB) signaling is an important signaling pathway that is involved in a variety of cellular processes including immune response, inflammation, and apoptosis. Recent studies revealed damped oscillations of NF-kB activity both experimentally and computationally, etc. In this work, based on a differential equation model, bifurcation analysis was used to examine whether it was possible for this system to produce sustained oscillations (limit cycle oscillations) rather than damped oscillations. Both one- and two-parameter bifurcation analyses have been performed and it was found that certain conditions could possibly result in sustained oscillations of nuclear NF-kB activity. The parameter regimes corresponding to such oscillations were calculated with this method.

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Lu B, Yue H, The National Natural Science Foundation of China (30770560) (Funder). A systematic approach in analyzing sustained oscillations in an NF-kB signal transduction pathway system. Acta Biophysica Sinica. 2010 May;26(5):406-420.