A sustainable and scalable multicomponent continuous flow process to access fused imidazoheterocycle pharmacophores

Blake J. M. Baker, William J. Kerr, David M. Lindsay, Vipulkumar K. Patel, Darren L. Poole

Research output: Contribution to journalArticlepeer-review

Abstract

Continuous flow processes constitute a powerful and increasingly popular approach to chemical synthesis within the bulk and petrochemical industries. In comparison to batch methods, they offer benefits in terms of thermal transfer, superior mixing, safe handling of dangerous reagents, and the potential for in-line analyses and facile route telescoping.1 Moreover, the inherent safety of flow reactions, as well as their reduced requirement for reaction volume, and the quantities of reagents and solvents used, makes them ideally aligned to the 12 principles of green chemistry.2 Despite these advantages, the majority of chemical processes within the pharmaceutical and fine chemical industries remain batch in nature.3 Based on this, the benefits of applying flow chemistry methods for the sustainable synthesis of pharmaceutically relevant compounds are yet to be fully realised.
Original languageEnglish
Number of pages8
JournalGreen Chemistry
Early online date4 Jan 2021
DOIs
Publication statusE-pub ahead of print - 4 Jan 2021

Keywords

  • continuous flow processes
  • medicinal chemistry
  • imidazoheterocycle

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