A sustainable and scalable multicomponent continuous flow process to access fused imidazoheterocycle pharmacophores

Blake J. M. Baker, William J. Kerr, David M. Lindsay, Vipulkumar K. Patel, Darren L. Poole

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)
4 Downloads (Pure)

Abstract

Described herein is a green, continuous flow process for the synthesis of various aminoimidazoheterocycles, through the Gröebke-Blackburn-Bienaymé reaction (GBBR). This multicomponent procedure combines aminoazines, aldehydes and isocyanides to generate a wide variety of medicinally privileged, aminated imidazoheterocycle architectures. This method is performed in ethanol, using only mineral acid rather than the standard metal-based catalysts typical to the field. These sustainability benefits have been demonstrated even on multigram scale, exemplifying the facile scalability of the procedure. The process also boasts shorter reaction times, wider scope robustness, and improved yields compared to the currently available methods, with no requirement for an aqueous work-up procedure, affording resulting scaffolds of notable relevance, to a range of medicinal targets of academic and industrial interest.

Original languageEnglish
Pages (from-to)280-287
Number of pages8
JournalGreen Chemistry
Volume23
Issue number1
Early online date4 Jan 2021
DOIs
Publication statusPublished - 7 Jan 2021

Keywords

  • continuous flow processes
  • medicinal chemistry
  • imidazoheterocycle

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