Difluorinated analogues of (hydroxymethyl)conduritols can be synthesised from selected furans and a difluorinated dienophile in two reaction steps.
- ring opening
- tandem cycloaddition
Fawcett, J., Moralee, A. C., Percy, J., Salafia, V., Vincent, M. A., & Hillier, I. H. (2004). A surprising steric effect on a tandem cycloaddition/ring-opening reaction: rapid syntheses of difluorinated analogues of (hydroxymethyl)conduritols. Chemical Communications, 2004(9), 1062-1063. https://doi.org/10.1039/b401245c