Abstract
| Language | English |
|---|---|
| Pages | 705-715 |
| Number of pages | 10 |
| Journal | Chromatographia |
| Volume | 70 |
| Issue number | 5-6 |
| DOIs | |
| Publication status | Published - Sep 2009 |
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Keywords
- column liquid chromatography
- retention behaviour and phase stability
- lipophilic interactions
- π–π interactions
- dipole–dipole interactions
- cyano phenyl and alkyl phases
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A study of the relative importance of lipophilic, π-π and dipole-dipole interactions on cyanopropyl, phenyl and alkyl LC phases bonded onto the same base silica. / Markopoulou, Catherine; Tweedle, Tracey; Watson, D.G.; Skellern, G.G.; Reda, Houssam; Petersson, Patrik; Bradstock, Hannah; Euerby, Melvin R.
In: Chromatographia, Vol. 70, No. 5-6, 09.2009, p. 705-715.Research output: Contribution to journal › Article
TY - JOUR
T1 - A study of the relative importance of lipophilic, π-π and dipole-dipole interactions on cyanopropyl, phenyl and alkyl LC phases bonded onto the same base silica
AU - Markopoulou, Catherine
AU - Tweedle, Tracey
AU - Watson, D.G.
AU - Skellern, G.G.
AU - Reda, Houssam
AU - Petersson, Patrik
AU - Bradstock, Hannah
AU - Euerby, Melvin R.
PY - 2009/9
Y1 - 2009/9
N2 - Cyano (CN), butyl (C4), phenyl and octadecyl (C18) phases prepared from the same base silica gel were chromatographically characterized in order to assess the relative importance of lipophilic, π-π and dipole-dipole interactions in governing retention on these differing phases. Dipole interactions of analytes (possessing dipole moments and low lipophilicity) with CN phases were primarily responsible for the elution order. However, as the analytes' lipophilicity increased, the lipophilic interaction predominated over the dipole interaction. In comparison, retention on the phenyl phase appeared to be complex, being controlled by a mixture of lipophilic, π-π and dipole-dipole interactions. Retention on the C4 and C18 phases was dictated by the analyte's lipophilicity and its accessibility into the phase.
AB - Cyano (CN), butyl (C4), phenyl and octadecyl (C18) phases prepared from the same base silica gel were chromatographically characterized in order to assess the relative importance of lipophilic, π-π and dipole-dipole interactions in governing retention on these differing phases. Dipole interactions of analytes (possessing dipole moments and low lipophilicity) with CN phases were primarily responsible for the elution order. However, as the analytes' lipophilicity increased, the lipophilic interaction predominated over the dipole interaction. In comparison, retention on the phenyl phase appeared to be complex, being controlled by a mixture of lipophilic, π-π and dipole-dipole interactions. Retention on the C4 and C18 phases was dictated by the analyte's lipophilicity and its accessibility into the phase.
KW - column liquid chromatography
KW - retention behaviour and phase stability
KW - lipophilic interactions
KW - π–π interactions
KW - dipole–dipole interactions
KW - cyano phenyl and alkyl phases
UR - http://www.chromatographia.de/
UR - http://dx.doi.org/10.1365/s10337-009-1224-7
U2 - 10.1365/s10337-009-1224-7
DO - 10.1365/s10337-009-1224-7
M3 - Article
VL - 70
SP - 705
EP - 715
JO - Chromatographia
T2 - Chromatographia
JF - Chromatographia
SN - 0009-5893
IS - 5-6
ER -