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Abstract
A novel method for the preparation of aminoalkylaminomethyl products was developed utilising novel Mannich-type salts featuring a R 2NCH 2NR 3 + moiety. This methodology showed good nucleophile scope and was successfully employed in reactions under basic, acidic, and neutral conditions. A wide range of diamine products was successfully synthesised, including a neuropeptide Y antagonist.
Original language | English |
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Article number | 133120 |
Number of pages | 17 |
Journal | Tetrahedron |
Volume | 128 |
Early online date | 5 Nov 2022 |
DOIs | |
Publication status | Published - 3 Dec 2022 |
Keywords
- Mannich salts
- trialkylamine
- nucleophile
- amminomethylammonium
- functionalisation
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Dive into the research topics of 'A study of the reactivity of cyclic aminomethylammonium mannich salts'. Together they form a unique fingerprint.Projects
- 1 Finished
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Industrial Case Account - University of Strathclyde 2019 | McMahon, Connor
Murphy, J. (Principal Investigator), Tuttle, T. (Co-investigator) & McMahon, C. (Research Co-investigator)
EPSRC (Engineering and Physical Sciences Research Council)
1/10/19 → 28/06/24
Project: Research Studentship Case - Internally allocated