A study of diketopiperazines as electron-donor initiators in transition metal-free haloarene-arene coupling

Florimond Cumine, Shengze Zhou, Tell Tuttle, John A. Murphy

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Abstract

Several diketopiperazines have been shown to promote carbon-carbon coupling between benzene and aryl halides in the presence of potassium tert-butoxide and without the assistance of a transition metal catalyst. The structure of the diketopiperazine has an influence on its reductive potential and can help to promote the coupling of the more challenging aryl bromides with benzene.
Original languageEnglish
Pages (from-to)3324 - 3336
Number of pages3
JournalOrganic and Biomolecular Chemistry
Volume15
Early online date29 Mar 2017
DOIs
Publication statusPublished - 19 Apr 2017

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Keywords

  • diketopiperazines
  • electron donors
  • carbon-carbon coupling
  • catalysts
  • aryl bromides
  • aryl halides
  • benzene

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