A statistical mechanics description of environmental variability in metabolic networks

J.J. Crofts, Ernesto Estrada

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2 Citations (Scopus)
48 Downloads (Pure)

Abstract

Many of the chemical reactions that take place within a living cell are
irreversible. Due to evolutionary pressures, the number of allowable reactions within these systems are highly constrained and thus the resulting metabolic networks display considerable asymmetry. In this paper, we explore possible evolutionary factors pertaining to the reduced symmetry observed in these networks, and demonstrate the important role environmental variability plays in shaping their structural organization. Interpreting the returnability index as an equilibrium constant for a reaction network in equilibrium with a hypothetical reference system, enables us to quantify the extent to which a metabolic network is in disequilibrium. Further, by introducing a new directed centrality measure via an extension of the subgraph centrality metric to directed networks, we are able to characterise individual metabolites by their participation within metabolic pathways. To demonstrate these ideas, we study 116 metabolic networks of bacteria. In particular, we find that the equilibrium constant for the metabolic networks decreases significantly in-line with variability in bacterial habitats, supporting the view that environmental variability promotes disequilibrium
within these biochemical reaction systems
Original languageEnglish
Pages (from-to)675-688
Number of pages14
JournalJournal of Mathematical Chemistry
Volume52
Issue number2
DOIs
Publication statusPublished - Feb 2014

Keywords

  • complexity
  • metabolic networks
  • returnability
  • centrality
  • statistical mechanics
  • environmental variability

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