A range of substituted propargyl alcohols form ethers with allyl bromide in good yields; conversion of these ethers to the alkyne hexacarbonyl dicobalt complexes using Co2(CO)8, followed by intramolecular cyclisation gives substituted 3-oxabicyclo[3.3.0]oct-6-en-7-ones (4a–4e) in fair to moderate yields.
- propargyl alcohols
- intramolecular cyclisation
Billington, D. C., & Willison, D. (1984). A simple organocobalt mediated synthesis of substituted 3-oxabicyclo[3.3.0]oct-6-en-7-ones. Tetrahedron Letters, 25(36), 4041-4044. https://doi.org/10.1016/0040-4039(84)80061-1