A simple method for the preparation of di-, tri-, and tetrasubstituted non-symmetrical ureas

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Abstract

The synthesis of a series of di-, tri-, and tetrasubstituted non-sym. ureas is described. Di- and trisubstituted ureas are prepd. in excellent yield by treatment of a Ph carbamate in a self-tunable single-mode microwave synthesizer with a primary or secondary amine. The synthetically more challenging tetrasubstituted urea can be prepd. using the 4-nitrophenyl carbamate and a secondary amine.
Original languageUndefined/Unknown
Pages (from-to)243-246
Number of pages4
JournalSynlett
Issue number2
DOIs
Publication statusPublished - 2006

Keywords

  • urea
  • carbamate
  • microwave-assisted synthesis

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