A RNA-based approach towards small molecule inhibitors

G. Mayer, D. Faulhammer, M. Grättinger, S. Fessele, M. Blind

Research output: Contribution to journalArticle

10 Citations (Scopus)


The identification of low-molecular-weight protein inhibitors for functional studies as well as for the generation of lead drug compounds is one of the most important tasks in chemical biology. We describe a generalized assay that utilizes inhibitory aptamers for the identification of small molecules with aptamer-inherited properties. These compounds share the functional profile of the aptamers and thus are considered as potent protein inhibitors.
Original languageEnglish
Pages (from-to)1993-1996
Number of pages3
Issue number12
Publication statusPublished - 2009


  • aptamers
  • high-throughput screening
  • protein inhibitors
  • RiboGreen

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    Mayer, G., Faulhammer, D., Grättinger, M., Fessele, S., & Blind, M. (2009). A RNA-based approach towards small molecule inhibitors. Chembiochem, 10(12), 1993-1996. https://doi.org/10.1002/cbic.200900325