A RNA-based approach towards small molecule inhibitors

G. Mayer, D. Faulhammer, M. Grättinger, S. Fessele, M. Blind

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The identification of low-molecular-weight protein inhibitors for functional studies as well as for the generation of lead drug compounds is one of the most important tasks in chemical biology. We describe a generalized assay that utilizes inhibitory aptamers for the identification of small molecules with aptamer-inherited properties. These compounds share the functional profile of the aptamers and thus are considered as potent protein inhibitors.
LanguageEnglish
Pages1993-1996
Number of pages3
JournalChembiochem
Volume10
Issue number12
DOIs
Publication statusPublished - 2009

Fingerprint

RNA
Molecules
Assays
Proteins
Molecular Weight
Molecular weight
Pharmaceutical Preparations
Lead

Keywords

  • aptamers
  • high-throughput screening
  • protein inhibitors
  • RiboGreen
  • SELEX

Cite this

Mayer, G., Faulhammer, D., Grättinger, M., Fessele, S., & Blind, M. (2009). A RNA-based approach towards small molecule inhibitors. Chembiochem, 10(12), 1993-1996. https://doi.org/10.1002/cbic.200900325
Mayer, G. ; Faulhammer, D. ; Grättinger, M. ; Fessele, S. ; Blind, M. / A RNA-based approach towards small molecule inhibitors. In: Chembiochem. 2009 ; Vol. 10, No. 12. pp. 1993-1996.
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Mayer, G, Faulhammer, D, Grättinger, M, Fessele, S & Blind, M 2009, 'A RNA-based approach towards small molecule inhibitors' Chembiochem, vol. 10, no. 12, pp. 1993-1996. https://doi.org/10.1002/cbic.200900325

A RNA-based approach towards small molecule inhibitors. / Mayer, G.; Faulhammer, D.; Grättinger, M.; Fessele, S.; Blind, M.

In: Chembiochem, Vol. 10, No. 12, 2009, p. 1993-1996.

Research output: Contribution to journalArticle

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T1 - A RNA-based approach towards small molecule inhibitors

AU - Mayer, G.

AU - Faulhammer, D.

AU - Grättinger, M.

AU - Fessele, S.

AU - Blind, M.

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AB - The identification of low-molecular-weight protein inhibitors for functional studies as well as for the generation of lead drug compounds is one of the most important tasks in chemical biology. We describe a generalized assay that utilizes inhibitory aptamers for the identification of small molecules with aptamer-inherited properties. These compounds share the functional profile of the aptamers and thus are considered as potent protein inhibitors.

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KW - high-throughput screening

KW - protein inhibitors

KW - RiboGreen

KW - SELEX

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DO - 10.1002/cbic.200900325

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JO - Chembiochem

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Mayer G, Faulhammer D, Grättinger M, Fessele S, Blind M. A RNA-based approach towards small molecule inhibitors. Chembiochem. 2009;10(12):1993-1996. https://doi.org/10.1002/cbic.200900325