A review of anti-inflammatory stratagies in cardiac surgery

G. Asimakopoulos, T. Gourlay

    Research output: Contribution to journalArticle

    34 Citations (Scopus)

    Abstract

    It is generally accepted that cardiac surgery is frequently associated with the development of systemic inflammatory response. This phenomenon is very variable clinically, and can be detected by measuring plasma concentrations of certain inflammatory markers. Complement component, cytokines and adhesion molecules are examples of these markers. Systemic inflammation can be potentially damaging to major organs. Several anti-inflammatory strategies have been used in recent years, aiming to attenuate the development of systemic inflammatory response. This article summarizes recently published literature concerning the use of anti-inflammatory techniques and pharmacological agents in cardiac surgery. In particular, the anti-inflammatory effects of off-pump surgery, leukocyte filtration, corticosteroids, aprotinin, phosphodiesterase inhibitors, dpoexamine, H2 antagonists and ACE inhibitors are reviewed. The overall conclusion is that although certain strategies reduce plasma levels of inflammatory mediators, convincing evidence of significant clinical benefits is yet to come.
    LanguageEnglish
    Pages7-12
    Number of pages5
    JournalPerfusion
    Volume1
    DOIs
    Publication statusPublished - 2003

    Fingerprint

    Surgery
    surgery
    Thoracic Surgery
    Anti-Inflammatory Agents
    Filtering Surgery
    Plasmas
    Aprotinin
    Phosphodiesterase Inhibitors
    Angiotensin-Converting Enzyme Inhibitors
    Adrenal Cortex Hormones
    Leukocytes
    Adhesion
    Pumps
    Pharmacology
    Cytokines
    Inflammation
    Molecules
    evidence
    literature

    Keywords

    • anti-inflammatory
    • cardiac surgery
    • heart disease
    • bioengineering
    • surgery

    Cite this

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    A review of anti-inflammatory stratagies in cardiac surgery. / Asimakopoulos, G.; Gourlay, T.

    In: Perfusion, Vol. 1, 2003, p. 7-12.

    Research output: Contribution to journalArticle

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