A record-linkage study of the development of hepatocellular carcinoma in persons with hepatitis C infection in Scotland

S.A. McDonald, S.J. Hutchinson, S.M. Bird, C. Robertson, P.R. Mills, J.F. Dillon, D.J. Goldberg, Chief Scientist Office (Funder), Medical Research Council (Funder)

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Abstract

We investigated trends in first time hospital admissions and deaths attributable to hepatocellular carcinoma (HCC) in a large population based cohort of 22 073 individuals diagnosed with hepatitis C viral (HCV) infection through laboratory testing in Scotland in 1991 2006. We identified new cases of HCC through record linkage to the national inpatient hospital discharge database and deaths registry. A total of 172 persons diagnosed with HCV were admitted to hospital or died with first time mention of HCC. Hepatocellular carcinoma incidence increased between 1996 and 2006 (average annual change of 6.1, 95% confidence interval (CI):0.9 11.6%, P¼0.021). The adjusted relative risk of HCC was greater for males (hazard ratio¼2.7, 95% CI: 1.7 4.2), for those aged 60 years or older (hazard ratio ¼2.7, 95% CI: 1.9 4.1) compared with 50 59 years, and for those with a previous alcohol related hospital admission (hazard ratio¼2.5, 95% CI: 1.7 3.7). The risk of individuals diagnosed with HCV developing HCC was greatlyincreased compared with the general Scottish population (standardised incidence ratio¼127, 95% CI: 102 156). Owing to the advancing age of the Scottish HCV diagnosed population, the annual number of HCC cases is projected to increase, with a consequent increasing burden on the public healthcare system.
Original languageEnglish
Pages (from-to)805-810
Number of pages6
JournalBritish Journal of Cancer
Volume99
DOIs
Publication statusPublished - 26 Aug 2008

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Scotland
Hepatitis C
Hepatocellular Carcinoma
Infection
Confidence Intervals
Population
Incidence
Virus Diseases
Registries
Inpatients
Alcohols
Databases
Delivery of Health Care

Keywords

  • hepatocellular carcinoma
  • hepatitis C
  • record linkage study
  • alcohol
  • medical research
  • statistics

Cite this

McDonald, S.A. ; Hutchinson, S.J. ; Bird, S.M. ; Robertson, C. ; Mills, P.R. ; Dillon, J.F. ; Goldberg, D.J. ; Chief Scientist Office (Funder) ; Medical Research Council (Funder). / A record-linkage study of the development of hepatocellular carcinoma in persons with hepatitis C infection in Scotland. In: British Journal of Cancer. 2008 ; Vol. 99. pp. 805-810.
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abstract = "We investigated trends in first time hospital admissions and deaths attributable to hepatocellular carcinoma (HCC) in a large population based cohort of 22 073 individuals diagnosed with hepatitis C viral (HCV) infection through laboratory testing in Scotland in 1991 2006. We identified new cases of HCC through record linkage to the national inpatient hospital discharge database and deaths registry. A total of 172 persons diagnosed with HCV were admitted to hospital or died with first time mention of HCC. Hepatocellular carcinoma incidence increased between 1996 and 2006 (average annual change of 6.1, 95{\%} confidence interval (CI):0.9 11.6{\%}, P¼0.021). The adjusted relative risk of HCC was greater for males (hazard ratio¼2.7, 95{\%} CI: 1.7 4.2), for those aged 60 years or older (hazard ratio ¼2.7, 95{\%} CI: 1.9 4.1) compared with 50 59 years, and for those with a previous alcohol related hospital admission (hazard ratio¼2.5, 95{\%} CI: 1.7 3.7). The risk of individuals diagnosed with HCV developing HCC was greatlyincreased compared with the general Scottish population (standardised incidence ratio¼127, 95{\%} CI: 102 156). Owing to the advancing age of the Scottish HCV diagnosed population, the annual number of HCC cases is projected to increase, with a consequent increasing burden on the public healthcare system.",
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McDonald, SA, Hutchinson, SJ, Bird, SM, Robertson, C, Mills, PR, Dillon, JF, Goldberg, DJ, Chief Scientist Office (Funder) & Medical Research Council (Funder) 2008, 'A record-linkage study of the development of hepatocellular carcinoma in persons with hepatitis C infection in Scotland', British Journal of Cancer, vol. 99, pp. 805-810. https://doi.org/10.1038/sj.bjc.6604563

A record-linkage study of the development of hepatocellular carcinoma in persons with hepatitis C infection in Scotland. / McDonald, S.A.; Hutchinson, S.J.; Bird, S.M.; Robertson, C.; Mills, P.R.; Dillon, J.F.; Goldberg, D.J.; Chief Scientist Office (Funder); Medical Research Council (Funder).

In: British Journal of Cancer, Vol. 99, 26.08.2008, p. 805-810.

Research output: Contribution to journalArticle

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T1 - A record-linkage study of the development of hepatocellular carcinoma in persons with hepatitis C infection in Scotland

AU - McDonald, S.A.

AU - Hutchinson, S.J.

AU - Bird, S.M.

AU - Robertson, C.

AU - Mills, P.R.

AU - Dillon, J.F.

AU - Goldberg, D.J.

AU - Chief Scientist Office (Funder)

AU - Medical Research Council (Funder)

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N2 - We investigated trends in first time hospital admissions and deaths attributable to hepatocellular carcinoma (HCC) in a large population based cohort of 22 073 individuals diagnosed with hepatitis C viral (HCV) infection through laboratory testing in Scotland in 1991 2006. We identified new cases of HCC through record linkage to the national inpatient hospital discharge database and deaths registry. A total of 172 persons diagnosed with HCV were admitted to hospital or died with first time mention of HCC. Hepatocellular carcinoma incidence increased between 1996 and 2006 (average annual change of 6.1, 95% confidence interval (CI):0.9 11.6%, P¼0.021). The adjusted relative risk of HCC was greater for males (hazard ratio¼2.7, 95% CI: 1.7 4.2), for those aged 60 years or older (hazard ratio ¼2.7, 95% CI: 1.9 4.1) compared with 50 59 years, and for those with a previous alcohol related hospital admission (hazard ratio¼2.5, 95% CI: 1.7 3.7). The risk of individuals diagnosed with HCV developing HCC was greatlyincreased compared with the general Scottish population (standardised incidence ratio¼127, 95% CI: 102 156). Owing to the advancing age of the Scottish HCV diagnosed population, the annual number of HCC cases is projected to increase, with a consequent increasing burden on the public healthcare system.

AB - We investigated trends in first time hospital admissions and deaths attributable to hepatocellular carcinoma (HCC) in a large population based cohort of 22 073 individuals diagnosed with hepatitis C viral (HCV) infection through laboratory testing in Scotland in 1991 2006. We identified new cases of HCC through record linkage to the national inpatient hospital discharge database and deaths registry. A total of 172 persons diagnosed with HCV were admitted to hospital or died with first time mention of HCC. Hepatocellular carcinoma incidence increased between 1996 and 2006 (average annual change of 6.1, 95% confidence interval (CI):0.9 11.6%, P¼0.021). The adjusted relative risk of HCC was greater for males (hazard ratio¼2.7, 95% CI: 1.7 4.2), for those aged 60 years or older (hazard ratio ¼2.7, 95% CI: 1.9 4.1) compared with 50 59 years, and for those with a previous alcohol related hospital admission (hazard ratio¼2.5, 95% CI: 1.7 3.7). The risk of individuals diagnosed with HCV developing HCC was greatlyincreased compared with the general Scottish population (standardised incidence ratio¼127, 95% CI: 102 156). Owing to the advancing age of the Scottish HCV diagnosed population, the annual number of HCC cases is projected to increase, with a consequent increasing burden on the public healthcare system.

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KW - hepatitis C

KW - record linkage study

KW - alcohol

KW - medical research

KW - statistics

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DO - 10.1038/sj.bjc.6604563

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JO - British Journal of Cancer

JF - British Journal of Cancer

SN - 0007-0920

ER -