A public-private partnership to unlock the untargeted kinome

Stefan Knapp, Paulo Arruda, Julian Blagg, Stephen Burley, David Drewery, Aled Edwards, Doriano Fabbro, Paul Gillespie, Nathanael S Gray, Bernhard Kuster, Karen E Lackey, Paulo Mazzafera, Nick Tomkinson, Timothy Willson, Paul Workman, William Zuercher

Research output: Contribution to journalArticle

96 Citations (Scopus)


Chemical probes are urgently needed to functionally annotate hitherto untargeted kinases and stimulate new drug discovery efforts to address unmet medical need. The size of the human kinome combined with the high cost associated with probe generation severely limits access to new probes. We propose a large scale public-private partnership as a new approach which offers economies of scale, minimized redundancy, and sharing of risk and cost.
Original languageEnglish
Pages (from-to)3-6
Number of pages4
JournalNature Chemical Biology
Issue number1
Publication statusPublished - Jan 2013


  • public-private partnership
  • untargeted kinome
  • chemical biology



  • 1 Organiser of major conference
  • 1 Participation in workshop, seminar, course

The Untargeted Kinome

Nick Tomkinson (Participant)

27 Mar 2012

Activity: Participating in or organising an event typesOrganiser of major conference

SMSdrug quarterly meeting

Nick Tomkinson (Participant)

7 Mar 2012

Activity: Participating in or organising an event typesParticipation in workshop, seminar, course

Cite this

Knapp, S., Arruda, P., Blagg, J., Burley, S., Drewery, D., Edwards, A., Fabbro, D., Gillespie, P., Gray, N. S., Kuster, B., Lackey, K. E., Mazzafera, P., Tomkinson, N., Willson, T., Workman, P., & Zuercher, W. (2013). A public-private partnership to unlock the untargeted kinome. Nature Chemical Biology, 9(1), 3-6. https://doi.org/10.1038/nchembio.1113