A public-private partnership to unlock the untargeted kinome

Stefan Knapp, Paulo Arruda, Julian Blagg, Stephen Burley, David Drewery, Aled Edwards, Doriano Fabbro, Paul Gillespie, Nathanael S Gray, Bernhard Kuster, Karen E Lackey, Paulo Mazzafera, Nick Tomkinson, Timothy Willson, Paul Workman, William Zuercher

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

Chemical probes are urgently needed to functionally annotate hitherto untargeted kinases and stimulate new drug discovery efforts to address unmet medical need. The size of the human kinome combined with the high cost associated with probe generation severely limits access to new probes. We propose a large scale public-private partnership as a new approach which offers economies of scale, minimized redundancy, and sharing of risk and cost.
LanguageEnglish
Pages3-6
Number of pages4
JournalNature Chemical Biology
Volume9
Issue number1
DOIs
Publication statusPublished - Jan 2013

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Public-Private Sector Partnerships
Cost Sharing
Drug Discovery
Phosphotransferases
Costs and Cost Analysis

Keywords

  • public-private partnership
  • untargeted kinome
  • chemical biology

Cite this

Knapp, S., Arruda, P., Blagg, J., Burley, S., Drewery, D., Edwards, A., ... Zuercher, W. (2013). A public-private partnership to unlock the untargeted kinome. Nature Chemical Biology, 9(1), 3-6. https://doi.org/10.1038/nchembio.1113
Knapp, Stefan ; Arruda, Paulo ; Blagg, Julian ; Burley, Stephen ; Drewery, David ; Edwards, Aled ; Fabbro, Doriano ; Gillespie, Paul ; Gray, Nathanael S ; Kuster, Bernhard ; Lackey, Karen E ; Mazzafera, Paulo ; Tomkinson, Nick ; Willson, Timothy ; Workman, Paul ; Zuercher, William. / A public-private partnership to unlock the untargeted kinome. In: Nature Chemical Biology. 2013 ; Vol. 9, No. 1. pp. 3-6.
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Knapp, S, Arruda, P, Blagg, J, Burley, S, Drewery, D, Edwards, A, Fabbro, D, Gillespie, P, Gray, NS, Kuster, B, Lackey, KE, Mazzafera, P, Tomkinson, N, Willson, T, Workman, P & Zuercher, W 2013, 'A public-private partnership to unlock the untargeted kinome' Nature Chemical Biology, vol. 9, no. 1, pp. 3-6. https://doi.org/10.1038/nchembio.1113

A public-private partnership to unlock the untargeted kinome. / Knapp, Stefan; Arruda, Paulo; Blagg, Julian; Burley, Stephen; Drewery, David; Edwards, Aled; Fabbro, Doriano; Gillespie, Paul; Gray, Nathanael S; Kuster, Bernhard; Lackey, Karen E ; Mazzafera, Paulo; Tomkinson, Nick; Willson, Timothy; Workman, Paul; Zuercher, William.

In: Nature Chemical Biology, Vol. 9, No. 1, 01.2013, p. 3-6.

Research output: Contribution to journalArticle

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Knapp S, Arruda P, Blagg J, Burley S, Drewery D, Edwards A et al. A public-private partnership to unlock the untargeted kinome. Nature Chemical Biology. 2013 Jan;9(1):3-6. https://doi.org/10.1038/nchembio.1113