TY - JOUR
T1 - A population-based matched cohort study of early pregnancy outcomes following COVID-19 vaccination and SARS-CoV-2 infection
AU - Calvert, Clara
AU - Carruthers, Jade
AU - Denny, Cheryl
AU - Donaghy, Jack
AU - Hillman, Sam
AU - Hopcroft, Lisa E. M.
AU - Hopkins, Leanne
AU - Goulding, Anna
AU - Lindsay, Laura
AU - McLaughlin, Terry
AU - Moore, Emily
AU - Pan, Jiafeng
AU - Taylor, Bob
AU - Almaghrabi, Fatima
AU - Auyeung, Bonnie
AU - Bhaskaran, Krishnan
AU - Gibbons, Cheryl L.
AU - Katikireddi, Srinivasa Vittal
AU - McCowan, Colin
AU - Murray, Josie
AU - O’Leary, Maureen
AU - Ritchie, Lewis D.
AU - Shah, Syed Ahmar
AU - Simpson, Colin R.
AU - Robertson, Chris
AU - Sheikh, Aziz
AU - Stock, Sarah J.
AU - Wood, Rachael
PY - 2022/10/17
Y1 - 2022/10/17
N2 - Data on the safety of COVID-19 vaccines in early pregnancy are limited. We conducted a national, population-based, matched cohort study assessing associations between COVID-19 vaccination and miscarriage prior to 20 weeks gestation and, separately, ectopic pregnancy. We identified women in Scotland vaccinated between 6 weeks preconception and 19 weeks 6 days gestation (for miscarriage; n = 18,780) or 2 weeks 6 days gestation (for ectopic; n = 10,570). Matched, unvaccinated women from the pre-pandemic and, separately, pandemic periods were used as controls. Here we show no association between vaccination and miscarriage (adjusted Odds Ratio [aOR], pre-pandemic controls = 1.02, 95% Confidence Interval [CI] = 0.96–1.09) or ectopic pregnancy (aOR = 1.13, 95% CI = 0.92–1.38). We undertook additional analyses examining confirmed SARS-CoV-2 infection as the exposure and similarly found no association with miscarriage or ectopic pregnancy. Our findings support current recommendations that vaccination remains the safest way for pregnant women to protect themselves and their babies from COVID-19.
AB - Data on the safety of COVID-19 vaccines in early pregnancy are limited. We conducted a national, population-based, matched cohort study assessing associations between COVID-19 vaccination and miscarriage prior to 20 weeks gestation and, separately, ectopic pregnancy. We identified women in Scotland vaccinated between 6 weeks preconception and 19 weeks 6 days gestation (for miscarriage; n = 18,780) or 2 weeks 6 days gestation (for ectopic; n = 10,570). Matched, unvaccinated women from the pre-pandemic and, separately, pandemic periods were used as controls. Here we show no association between vaccination and miscarriage (adjusted Odds Ratio [aOR], pre-pandemic controls = 1.02, 95% Confidence Interval [CI] = 0.96–1.09) or ectopic pregnancy (aOR = 1.13, 95% CI = 0.92–1.38). We undertook additional analyses examining confirmed SARS-CoV-2 infection as the exposure and similarly found no association with miscarriage or ectopic pregnancy. Our findings support current recommendations that vaccination remains the safest way for pregnant women to protect themselves and their babies from COVID-19.
KW - COVID-19
KW - pregnancy
KW - early pregnancy outcomes
KW - miscarriage
KW - Scotland
U2 - 10.1038/s41467-022-33937-y
DO - 10.1038/s41467-022-33937-y
M3 - Article
SN - 2041-1723
VL - 13
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 6124
ER -
