A pilot study on clinical and neurological effects of neurofeedback training for treatment of central neuropathic pain

Aleksandra Vuckovic; Muhammad A. Hasan; Matthew Fraser; Bernie Conway; David B. Allan

doi:10.1007/978-3-319-08072-7_113

A pilot study on clinical and neurological effects of neurofeedback training for treatment of central neuropathic pain

Aleksandra Vuckovic^*, Muhammad A. Hasan, Matthew Fraser, Bernie Conway, David B. Allan

^*Corresponding author for this work

Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution book

Abstract

The aim of the study was to investigate the effect of neurofeedback training on central neuropathic pain in patients with chronic paraplegia. Patients EEG activity was modulated from the central areas of the cortex, electrode location C3/Cz/C4. Training consisted of reducing EEG power in theta (4-8 Hz) and higher beta (20-30 Hz) frequency ranges and increasing power in the higher alpha range (9-12 Hz). Patients received 20-40 neurofeedback treatment and four out of five patients reported clinically significant reduction of pain (>30%). EEG during neurofeedback revealed a wide spread modulation of power in all three frequency bands accompanied with changes in the coherence. LORETA analysis of EEG before and after neurofeedback therapy revealed general reduction of power in all frequency bands, most notably in 12-15 Hz and 20-30 Hz bands. Areas with reduced power included the Anterior Cingulate Cortex and the Insular Cortex, known to be involved in processing of chronic pain. Further studies on larger number of patients will be needed to confirm clinical relevance of neurofeedback therapy for treatment of central neuropathic pain.

Original language	English
Title of host publication	Replace, Repair, Restore, Relieve – Bridging Clinical and Engineering Solutions in Neurorehabilitation
Subtitle of host publication	Proceedings of the 2nd International Conference on NeuroRehabilitation (ICNR2014), Aalborg, 24-26 June, 2014
Editors	Winnie Jensen, Ole Kæseler Andersen, Metin Akay
Place of Publication	Cham, Switzerland
Publisher	Springer
Pages	823-831
Number of pages	9
ISBN (Print)	9783319080710
DOIs	https://doi.org/10.1007/978-3-319-08072-7_113
Publication status	Published - 10 Jul 2014

Publication series

Name	Biosystems and Biorobotics
ISSN (Print)	2195-3562

Funding

Acknowledgment. This work has been partially supported by the MRC grant G0902257/1, the Glasgow Research Partnership in Engineering and by NED University of Pakistan PhD scholarship. We thank Dr Purcell and Dr Mclean for choosing participants of the study and to all participants.

Keywords

complex regional pain syndrome
primary motor cortex
alpha band
beta band
neurofeedback training

Access to Document

10.1007/978-3-319-08072-7_113

Cite this

Vuckovic, A., Hasan, M. A., Fraser, M., Conway, B., & Allan, D. B. (2014). A pilot study on clinical and neurological effects of neurofeedback training for treatment of central neuropathic pain. In W. Jensen, O. K. Andersen, & M. Akay (Eds.), Replace, Repair, Restore, Relieve – Bridging Clinical and Engineering Solutions in Neurorehabilitation: Proceedings of the 2nd International Conference on NeuroRehabilitation (ICNR2014), Aalborg, 24-26 June, 2014 (pp. 823-831). (Biosystems and Biorobotics). Springer. https://doi.org/10.1007/978-3-319-08072-7_113

Vuckovic, Aleksandra ; Hasan, Muhammad A. ; Fraser, Matthew et al. / A pilot study on clinical and neurological effects of neurofeedback training for treatment of central neuropathic pain. Replace, Repair, Restore, Relieve – Bridging Clinical and Engineering Solutions in Neurorehabilitation: Proceedings of the 2nd International Conference on NeuroRehabilitation (ICNR2014), Aalborg, 24-26 June, 2014. editor / Winnie Jensen ; Ole Kæseler Andersen ; Metin Akay. Cham, Switzerland : Springer, 2014. pp. 823-831 (Biosystems and Biorobotics).

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abstract = "The aim of the study was to investigate the effect of neurofeedback training on central neuropathic pain in patients with chronic paraplegia. Patients EEG activity was modulated from the central areas of the cortex, electrode location C3/Cz/C4. Training consisted of reducing EEG power in theta (4-8 Hz) and higher beta (20-30 Hz) frequency ranges and increasing power in the higher alpha range (9-12 Hz). Patients received 20-40 neurofeedback treatment and four out of five patients reported clinically significant reduction of pain (>30%). EEG during neurofeedback revealed a wide spread modulation of power in all three frequency bands accompanied with changes in the coherence. LORETA analysis of EEG before and after neurofeedback therapy revealed general reduction of power in all frequency bands, most notably in 12-15 Hz and 20-30 Hz bands. Areas with reduced power included the Anterior Cingulate Cortex and the Insular Cortex, known to be involved in processing of chronic pain. Further studies on larger number of patients will be needed to confirm clinical relevance of neurofeedback therapy for treatment of central neuropathic pain.",

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Vuckovic, A, Hasan, MA, Fraser, M, Conway, B & Allan, DB 2014, A pilot study on clinical and neurological effects of neurofeedback training for treatment of central neuropathic pain. in W Jensen, OK Andersen & M Akay (eds), Replace, Repair, Restore, Relieve – Bridging Clinical and Engineering Solutions in Neurorehabilitation: Proceedings of the 2nd International Conference on NeuroRehabilitation (ICNR2014), Aalborg, 24-26 June, 2014. Biosystems and Biorobotics, Springer, Cham, Switzerland, pp. 823-831. https://doi.org/10.1007/978-3-319-08072-7_113

A pilot study on clinical and neurological effects of neurofeedback training for treatment of central neuropathic pain. / Vuckovic, Aleksandra; Hasan, Muhammad A.; Fraser, Matthew et al.
Replace, Repair, Restore, Relieve – Bridging Clinical and Engineering Solutions in Neurorehabilitation: Proceedings of the 2nd International Conference on NeuroRehabilitation (ICNR2014), Aalborg, 24-26 June, 2014. ed. / Winnie Jensen; Ole Kæseler Andersen; Metin Akay. Cham, Switzerland: Springer, 2014. p. 823-831 (Biosystems and Biorobotics).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution book

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Vuckovic A, Hasan MA, Fraser M, Conway B, Allan DB. A pilot study on clinical and neurological effects of neurofeedback training for treatment of central neuropathic pain. In Jensen W, Andersen OK, Akay M, editors, Replace, Repair, Restore, Relieve – Bridging Clinical and Engineering Solutions in Neurorehabilitation: Proceedings of the 2nd International Conference on NeuroRehabilitation (ICNR2014), Aalborg, 24-26 June, 2014. Cham, Switzerland: Springer. 2014. p. 823-831. (Biosystems and Biorobotics). doi: 10.1007/978-3-319-08072-7_113

A pilot study on clinical and neurological effects of neurofeedback training for treatment of central neuropathic pain

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