A parallel group randomised open blinded evaluation of acceptance and commitment therapy for depression after psychosis: a pilot trial protocol (ADAPT)

Andrew Gumley, Ross White, Andy Briggs, Ian Ford, Sarah Barry, Corinna Stewart, Sara Beedie, Caoimhe Clarke, Rachel Macleod, Emma Lidstone, Hamish McLeod

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Abstract

Background: Depression is one of the major contributors to poorer quality of life among individuals with psychosis and schizophrenia. Aims: This study protocol was designed as a pilot trial to determine the parameters of a larger, definitive pragmatic multi-centre randomised controlled trial of Acceptance and Commitment Therapy for depression after psychosis (ACTdp) for individuals with a diagnosis of schizophrenia who also meet diagnostic criteria for major depression. Methods: The study protocol was registered before initiating recruitment and was designed as a Parallel-group Randomised Open Blinded Evaluation (PROBE) comparing ACTdp plus standard care (SC) or SC alone. Participants were required to meet DSM-IV-TR criteria for schizophrenia and major depression (confirmed by Structured Clinical Interview for DSM/SCID-I and Calgary Depression Scale for Schizophrenia; score gt; 7). Blinded follow-ups are undertaken at 5 months (end of treatment) and at 10 months (5 months post treatment). Implications: The pilot aims to establish the basis for a larger-scale multi-centre randomised controlled trial of ACTdp. The most important study outcomes that will provide the basis of informing progression to a full trial are identified a priori as Population, Intervention, Control and Outcomes (PICO).
Original languageEnglish
Pages (from-to)143-155
Number of pages13
JournalPsychosis
Volume8
Issue number2
Early online date28 Oct 2015
DOIs
Publication statusPublished - 2016

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Keywords

  • schizophrenia
  • depression
  • randomised controlled trial
  • pilot
  • acceptanc and commitment therapy

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