A paracetamol-morpholine adduct

I D H Oswald, W D S Motherwell, S Parsons, C R Pulham

Research output: Contribution to journalArticlepeer-review


Paracetamol [also known as acetaminophen or N-(4-hydroxyphenyl) acetamide] is an important analgesic drug that has recently been cocrystallized with a series of cyclic N- and Odonor compounds. This paper describes the formation of a
paracetamol adduct with morpholine, viz. paracetamol± morpholine (1/2.5), C8H9NO22.5C4H9NO. There are ®ve morpholine molecules and two paracetamol molecules in the unit cell. The paracetamol molecules are held together by
hydrogen bonding via morpholine molecules, one of which is disordered about an inversion centre.
Original languageEnglish
Pages (from-to)O1290-O1292
Number of pages3
JournalActa Crystallographica Section E: Structure Reports
Issue numberPart 11
Early online date15 Oct 2002
Publication statusPublished - Nov 2002


  • crystals
  • acetaminophen
  • N-(4-hydroxyphenyl)acetamide
  • cocrystallized
  • paracetamol


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