A one-pot tandem chemoselective allylation/cross-coupling via temperature control of a multi-nucleophile/electrophile system

Chao Xu, James W.B. Fyfe, Ciaran P. Seath, Steven H. Bennett, Allan J.B. Watson

Research output: Contribution to journalArticle

2 Citations (Scopus)
8 Downloads (Pure)

Abstract

A chemoselective tandem reaction of a multi-reactive, two electrophile + two nucleophile, system is reported. An allylation/cross-coupling process of a haloaryl aldehyde, an aryl BPin, and an allyl BPin can be controlled using a temperature gradient to overcome natural reactivity profiles and allow two sequential chemoselective C–C bond formations without intervention. This process offers efficient access to an array of functionalised products including pharmaceutical and natural product scaffolds.
Original languageEnglish
Pages (from-to)9139-9142
Number of pages4
JournalChemical Communications (London)
Volume53
DOIs
Publication statusPublished - 26 Jul 2017

Keywords

  • chemoselective tandem reaction
  • bond formations
  • organoboron compounds

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