A one-pot Suzuki-hydrogenolysis protocol for the modular synthesis of 2,5-diaryltetrazoles

Keith Livingstone, Sophie Bertrand, Craig Jamieson

Research output: Contribution to journalArticle

Abstract

2,5-Diaryltetrazoles are a diverse range of compounds of considerable interest within the field of photochemistry as a valuable precursor of the nitrile imine 1,3-dipole. Current literature approaches toward this heterocycle remain unsuitable for the practical synthesis of a library of these derivatives. Herein, we disclose the development of a modular approach toward 2,5-diaryltetrazoles compatible with an array-type protocol, facilitated by a tandem Suzuki-hydrogenolysis approach.

Original languageEnglish
Pages (from-to)7413-7423
Number of pages11
JournalJournal of Organic Chemistry
Volume85
Issue number11
Early online date21 May 2020
DOIs
Publication statusE-pub ahead of print - 21 May 2020

Keywords

  • 2,5-diaryltetrazoles
  • photochemistry
  • modular approach

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