A numerical approach for the assessment of obesity-induced vascular changes in children

Research output: Contribution to conferenceAbstract

Abstract

Obesity in children and adolescents has taken epidemic proportions in recent years and has become one of the major challenges of the 21st century. Primarily a dietary disease, obesity is believed to accelerate the initiation and progression of endothelial dysfunction [1], one of the early biological markers for atherosclerotic lesions that underlie most cardiovascular diseases. Several markers have been proposed to help the clinical assessment of endothelial damage in high-risk paediatric patients. In obese children, arterial changes can painlessly be evaluated with measurements of the aortic and carotid intima-media thickness (IMT) and flowmediated dilatation (FMD) of the brachial, radial and femoral arteries [2]. Pulse wave analysis is additionally utilised to assess arterial stiffness, distensibility and compliance. This study observes childhood obesity under the magnifying lens of blood flow mechanics associated with obesity-induced vascular changes. The scope is to develop a safe and high-fidelity multi-scale computational tool for prognostic markers and predictive personalised care of obesity-related cardiovascular diseases, and transfer it into the paediatric reality. The current presentation will discuss a computational model of an arterial conduit during FDM.

Conference

Conference8th World Congress of Biomechanics
Abbreviated titleWCB
CountryIreland
CityDublin
Period8/07/1812/07/18
Internet address

Fingerprint

Pediatrics
Frequency division multiplexing
Lenses
Mechanics
Blood
Stiffness
Compliance

Keywords

  • obesity
  • cardiovascular diseaes
  • paediatrics

Cite this

Kazakidi, A. (Accepted/In press). A numerical approach for the assessment of obesity-induced vascular changes in children. Abstract from 8th World Congress of Biomechanics, Dublin, Ireland.
Kazakidi, Asimina. / A numerical approach for the assessment of obesity-induced vascular changes in children. Abstract from 8th World Congress of Biomechanics, Dublin, Ireland.1 p.
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note = "8th World Congress of Biomechanics, WCB ; Conference date: 08-07-2018 Through 12-07-2018",
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Kazakidi, A 2018, 'A numerical approach for the assessment of obesity-induced vascular changes in children' 8th World Congress of Biomechanics, Dublin, Ireland, 8/07/18 - 12/07/18, .

A numerical approach for the assessment of obesity-induced vascular changes in children. / Kazakidi, Asimina.

2018. Abstract from 8th World Congress of Biomechanics, Dublin, Ireland.

Research output: Contribution to conferenceAbstract

TY - CONF

T1 - A numerical approach for the assessment of obesity-induced vascular changes in children

AU - Kazakidi, Asimina

PY - 2018/3/13

Y1 - 2018/3/13

N2 - Obesity in children and adolescents has taken epidemic proportions in recent years and has become one of the major challenges of the 21st century. Primarily a dietary disease, obesity is believed to accelerate the initiation and progression of endothelial dysfunction [1], one of the early biological markers for atherosclerotic lesions that underlie most cardiovascular diseases. Several markers have been proposed to help the clinical assessment of endothelial damage in high-risk paediatric patients. In obese children, arterial changes can painlessly be evaluated with measurements of the aortic and carotid intima-media thickness (IMT) and flowmediated dilatation (FMD) of the brachial, radial and femoral arteries [2]. Pulse wave analysis is additionally utilised to assess arterial stiffness, distensibility and compliance. This study observes childhood obesity under the magnifying lens of blood flow mechanics associated with obesity-induced vascular changes. The scope is to develop a safe and high-fidelity multi-scale computational tool for prognostic markers and predictive personalised care of obesity-related cardiovascular diseases, and transfer it into the paediatric reality. The current presentation will discuss a computational model of an arterial conduit during FDM.

AB - Obesity in children and adolescents has taken epidemic proportions in recent years and has become one of the major challenges of the 21st century. Primarily a dietary disease, obesity is believed to accelerate the initiation and progression of endothelial dysfunction [1], one of the early biological markers for atherosclerotic lesions that underlie most cardiovascular diseases. Several markers have been proposed to help the clinical assessment of endothelial damage in high-risk paediatric patients. In obese children, arterial changes can painlessly be evaluated with measurements of the aortic and carotid intima-media thickness (IMT) and flowmediated dilatation (FMD) of the brachial, radial and femoral arteries [2]. Pulse wave analysis is additionally utilised to assess arterial stiffness, distensibility and compliance. This study observes childhood obesity under the magnifying lens of blood flow mechanics associated with obesity-induced vascular changes. The scope is to develop a safe and high-fidelity multi-scale computational tool for prognostic markers and predictive personalised care of obesity-related cardiovascular diseases, and transfer it into the paediatric reality. The current presentation will discuss a computational model of an arterial conduit during FDM.

KW - obesity

KW - cardiovascular diseaes

KW - paediatrics

UR - http://wcb2018.com/

M3 - Abstract

ER -

Kazakidi A. A numerical approach for the assessment of obesity-induced vascular changes in children. 2018. Abstract from 8th World Congress of Biomechanics, Dublin, Ireland.