A novel therapeutic approach to cytokine modulation in articular inflammation using filarial nematode derived ES-62

I.B. McInnes; J.A. Gracie; B.P. Leung; M. Harnett; F.Y. Liew; W. Harnett

doi:10.1186/ar682

A novel therapeutic approach to cytokine modulation in articular inflammation using filarial nematode derived ES-62

I.B. McInnes
, J.A. Gracie
, B.P. Leung
, M. Harnett
, F.Y. Liew
, W. Harnett

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Conference abstract › peer-review

1 Citation (Scopus)

44 Downloads (Pure)

Abstract

Discovering safe, novel immunomodulators that are effective in RA is currently a major therapeutic objective. Long-term immune system deviation is most striking in the host-parasite relationship, in which microbes may coexist with a human host. ES-62 exhibited powerful immunomodulation of CIA, preventing initiation of inflammatory arthritis. Crucially, ES-62 suppressed even established disease. These effects were due to inhibition of cytokine release, specifically TNF-α, and reversal of collagen specific Th1 responses associated with reduced expression of IFN-γ. The physiologic relevance of these observations was confirmed, as ES-62 down-regulated the release of proinflammatory cytokines (TNF-α and IL-6) from patient-derived samples.

Original language	English
Pages (from-to)	52-52
Number of pages	1
Journal	Arthritis Research and Therapy
Volume	5
Issue number	Suppl 1
DOIs	https://doi.org/10.1186/ar682
Publication status	Published - 24 Feb 2003
Event	23rd European Workshop for Rheumatology Research - Marseille, France Duration: 27 Mar 2003 → …

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

cytokine modulation
physiology
immunology
articular inflammation

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10.1186/ar682

strathprints003133.docAccepted author manuscript, 31 KB

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title = "A novel therapeutic approach to cytokine modulation in articular inflammation using filarial nematode derived ES-62",

abstract = "Discovering safe, novel immunomodulators that are effective in RA is currently a major therapeutic objective. Long-term immune system deviation is most striking in the host-parasite relationship, in which microbes may coexist with a human host. ES-62 exhibited powerful immunomodulation of CIA, preventing initiation of inflammatory arthritis. Crucially, ES-62 suppressed even established disease. These effects were due to inhibition of cytokine release, specifically TNF-α, and reversal of collagen specific Th1 responses associated with reduced expression of IFN-γ. The physiologic relevance of these observations was confirmed, as ES-62 down-regulated the release of proinflammatory cytokines (TNF-α and IL-6) from patient-derived samples.",

keywords = "cytokine modulation, physiology, immunology, articular inflammation",

author = "I.B. McInnes and J.A. Gracie and B.P. Leung and M. Harnett and F.Y. Liew and W. Harnett",

note = "Meeting abstract presented at: 23rd European Workshop for Rheumatology Research, Marseille, France. 27 February – 2 March 2003. Variant of 133977; 23rd European Workshop for Rheumatology Research ; Conference date: 27-03-2003",

year = "2003",

month = feb,

day = "24",

doi = "10.1186/ar682",

language = "English",

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journal = "Arthritis Research and Therapy",

issn = "1478-6354",

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}

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T1 - A novel therapeutic approach to cytokine modulation in articular inflammation using filarial nematode derived ES-62

AU - McInnes, I.B.

AU - Gracie, J.A.

AU - Leung, B.P.

AU - Harnett, M.

AU - Liew, F.Y.

AU - Harnett, W.

N1 - Meeting abstract presented at: 23rd European Workshop for Rheumatology Research, Marseille, France. 27 February – 2 March 2003. Variant of 133977

PY - 2003/2/24

Y1 - 2003/2/24

N2 - Discovering safe, novel immunomodulators that are effective in RA is currently a major therapeutic objective. Long-term immune system deviation is most striking in the host-parasite relationship, in which microbes may coexist with a human host. ES-62 exhibited powerful immunomodulation of CIA, preventing initiation of inflammatory arthritis. Crucially, ES-62 suppressed even established disease. These effects were due to inhibition of cytokine release, specifically TNF-α, and reversal of collagen specific Th1 responses associated with reduced expression of IFN-γ. The physiologic relevance of these observations was confirmed, as ES-62 down-regulated the release of proinflammatory cytokines (TNF-α and IL-6) from patient-derived samples.

AB - Discovering safe, novel immunomodulators that are effective in RA is currently a major therapeutic objective. Long-term immune system deviation is most striking in the host-parasite relationship, in which microbes may coexist with a human host. ES-62 exhibited powerful immunomodulation of CIA, preventing initiation of inflammatory arthritis. Crucially, ES-62 suppressed even established disease. These effects were due to inhibition of cytokine release, specifically TNF-α, and reversal of collagen specific Th1 responses associated with reduced expression of IFN-γ. The physiologic relevance of these observations was confirmed, as ES-62 down-regulated the release of proinflammatory cytokines (TNF-α and IL-6) from patient-derived samples.

KW - cytokine modulation

KW - physiology

KW - immunology

KW - articular inflammation

U2 - 10.1186/ar682

DO - 10.1186/ar682

M3 - Conference abstract

SN - 1478-6354

VL - 5

SP - 52

EP - 52

JO - Arthritis Research and Therapy

JF - Arthritis Research and Therapy

IS - Suppl 1

T2 - 23rd European Workshop for Rheumatology Research

Y2 - 27 March 2003

ER -

A novel therapeutic approach to cytokine modulation in articular inflammation using filarial nematode derived ES-62

Abstract

UN SDGs

Keywords

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