Discovering safe, novel immunomodulators that are effective in RA is currently a major therapeutic objective. Long-term immune system deviation is most striking in the host-parasite relationship, in which microbes may coexist with a human host. ES-62 exhibited powerful immunomodulation of CIA, preventing initiation of inflammatory arthritis. Crucially, ES-62 suppressed even established disease. These effects were due to inhibition of cytokine release, specifically TNF-α, and reversal of collagen specific Th1 responses associated with reduced expression of IFN-γ. The physiologic relevance of these observations was confirmed, as ES-62 down-regulated the release of proinflammatory cytokines (TNF-α and IL-6) from patient-derived samples.
- cytokine modulation
- articular inflammation
McInnes, I. B., Gracie, J. A., Leung, B. P., Harnett, M. M., Liew, F. Y., & Harnett, W. (2003). A novel therapeutic approach to cytokine modulation in articular inflammation using filarial nematode derived ES-62. Arthritis Research and Therapy, 5(Suppl 1), 52-52. https://doi.org/10.1186/ar2988