A novel therapeutic approach to cytokine modulation in articular inflammation using filarial nematode derived ES-62

I.B. McInnes, J.A. Gracie, B.P. Leung, M.M. Harnett, F.Y. Liew, W. Harnett

Research output: Contribution to journalArticle

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Abstract

Discovering safe, novel immunomodulators that are effective in RA is currently a major therapeutic objective. Long-term immune system deviation is most striking in the host-parasite relationship, in which microbes may coexist with a human host. ES-62 exhibited powerful immunomodulation of CIA, preventing initiation of inflammatory arthritis. Crucially, ES-62 suppressed even established disease. These effects were due to inhibition of cytokine release, specifically TNF-α, and reversal of collagen specific Th1 responses associated with reduced expression of IFN-γ. The physiologic relevance of these observations was confirmed, as ES-62 down-regulated the release of proinflammatory cytokines (TNF-α and IL-6) from patient-derived samples.
Original languageEnglish
Pages (from-to)52-52
Number of pages0
JournalArthritis Research and Therapy
Volume5
Issue numberSuppl 1
DOIs
Publication statusPublished - 2003

Keywords

  • cytokine modulation
  • physiology
  • immunology
  • articular inflammation

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