A novel therapeutic approach to cytokine modulation in articular inflammation using filarial nematode derived ES-62

I.B. McInnes, J.A. Gracie, B.P. Leung, M.M. Harnett, F.Y. Liew, W. Harnett

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Discovering safe, novel immunomodulators that are effective in RA is currently a major therapeutic objective. Long-term immune system deviation is most striking in the host-parasite relationship, in which microbes may coexist with a human host. ES-62 exhibited powerful immunomodulation of CIA, preventing initiation of inflammatory arthritis. Crucially, ES-62 suppressed even established disease. These effects were due to inhibition of cytokine release, specifically TNF-α, and reversal of collagen specific Th1 responses associated with reduced expression of IFN-γ. The physiologic relevance of these observations was confirmed, as ES-62 down-regulated the release of proinflammatory cytokines (TNF-α and IL-6) from patient-derived samples.
LanguageEnglish
Pages52-52
Number of pages0
JournalArthritis Research and Therapy
Volume5
Issue numberSuppl 1
DOIs
Publication statusPublished - 2003

Fingerprint

Tumor Necrosis Factor-alpha
Joints
Cytokines
Inflammation
Host-Parasite Interactions
Immunomodulation
Immunologic Factors
Arthritis
Immune System
Interleukin-6
Collagen
Therapeutics

Keywords

  • cytokine modulation
  • physiology
  • immunology
  • articular inflammation

Cite this

McInnes, I.B. ; Gracie, J.A. ; Leung, B.P. ; Harnett, M.M. ; Liew, F.Y. ; Harnett, W. / A novel therapeutic approach to cytokine modulation in articular inflammation using filarial nematode derived ES-62. In: Arthritis Research and Therapy. 2003 ; Vol. 5, No. Suppl 1. pp. 52-52.
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abstract = "Discovering safe, novel immunomodulators that are effective in RA is currently a major therapeutic objective. Long-term immune system deviation is most striking in the host-parasite relationship, in which microbes may coexist with a human host. ES-62 exhibited powerful immunomodulation of CIA, preventing initiation of inflammatory arthritis. Crucially, ES-62 suppressed even established disease. These effects were due to inhibition of cytokine release, specifically TNF-α, and reversal of collagen specific Th1 responses associated with reduced expression of IFN-γ. The physiologic relevance of these observations was confirmed, as ES-62 down-regulated the release of proinflammatory cytokines (TNF-α and IL-6) from patient-derived samples.",
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A novel therapeutic approach to cytokine modulation in articular inflammation using filarial nematode derived ES-62. / McInnes, I.B.; Gracie, J.A.; Leung, B.P.; Harnett, M.M.; Liew, F.Y.; Harnett, W.

In: Arthritis Research and Therapy, Vol. 5, No. Suppl 1, 2003, p. 52-52.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A novel therapeutic approach to cytokine modulation in articular inflammation using filarial nematode derived ES-62

AU - McInnes, I.B.

AU - Gracie, J.A.

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AU - Liew, F.Y.

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AB - Discovering safe, novel immunomodulators that are effective in RA is currently a major therapeutic objective. Long-term immune system deviation is most striking in the host-parasite relationship, in which microbes may coexist with a human host. ES-62 exhibited powerful immunomodulation of CIA, preventing initiation of inflammatory arthritis. Crucially, ES-62 suppressed even established disease. These effects were due to inhibition of cytokine release, specifically TNF-α, and reversal of collagen specific Th1 responses associated with reduced expression of IFN-γ. The physiologic relevance of these observations was confirmed, as ES-62 down-regulated the release of proinflammatory cytokines (TNF-α and IL-6) from patient-derived samples.

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KW - immunology

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