A novel microfluidic drug testing platform for studying communication between independent neural networks

Research output: Contribution to conferencePaper

Abstract

Many in-vitro systems used during pre-clinical trials fail to recreate the biological complexity of the in-vivo neural microenvironment.Taking advantage of recent advances in microfluidic technology, we seek to develop a perfusion based drug discovery platform that is capable of high-throughput pharmacological profiling. This in turn will allow us to better understand how drugs influence the communication between functionally connected neural networks.

Conference

Conference10th FENS (Federation of European Neuroscience Societies) Forum of Neuroscience 2016
CountryDenmark
CityCopenhagen
Period2/07/166/07/16

Fingerprint

Microfluidics
Drug Discovery
Perfusion
Throughput
Clinical Trials
Pharmacology
Technology
Neural networks
Communication
Testing
Pharmaceutical Preparations
In Vitro Techniques

Keywords

  • microfluid drug testing
  • drug discovery programs
  • microfluidic array

Cite this

MacKerron, C., Robertson, G., Bushell, T., & Zagnoni, M. (2016). A novel microfluidic drug testing platform for studying communication between independent neural networks. Paper presented at 10th FENS (Federation of European Neuroscience Societies) Forum of Neuroscience 2016, Copenhagen, Denmark.
MacKerron, Christopher ; Robertson, Graham ; Bushell, Trevor ; Zagnoni, Michele. / A novel microfluidic drug testing platform for studying communication between independent neural networks. Paper presented at 10th FENS (Federation of European Neuroscience Societies) Forum of Neuroscience 2016, Copenhagen, Denmark.
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MacKerron, C, Robertson, G, Bushell, T & Zagnoni, M 2016, 'A novel microfluidic drug testing platform for studying communication between independent neural networks' Paper presented at 10th FENS (Federation of European Neuroscience Societies) Forum of Neuroscience 2016, Copenhagen, Denmark, 2/07/16 - 6/07/16, .

A novel microfluidic drug testing platform for studying communication between independent neural networks. / MacKerron, Christopher; Robertson, Graham; Bushell, Trevor; Zagnoni, Michele.

2016. Paper presented at 10th FENS (Federation of European Neuroscience Societies) Forum of Neuroscience 2016, Copenhagen, Denmark.

Research output: Contribution to conferencePaper

TY - CONF

T1 - A novel microfluidic drug testing platform for studying communication between independent neural networks

AU - MacKerron, Christopher

AU - Robertson, Graham

AU - Bushell, Trevor

AU - Zagnoni, Michele

PY - 2016/7/2

Y1 - 2016/7/2

N2 - Many in-vitro systems used during pre-clinical trials fail to recreate the biological complexity of the in-vivo neural microenvironment.Taking advantage of recent advances in microfluidic technology, we seek to develop a perfusion based drug discovery platform that is capable of high-throughput pharmacological profiling. This in turn will allow us to better understand how drugs influence the communication between functionally connected neural networks.

AB - Many in-vitro systems used during pre-clinical trials fail to recreate the biological complexity of the in-vivo neural microenvironment.Taking advantage of recent advances in microfluidic technology, we seek to develop a perfusion based drug discovery platform that is capable of high-throughput pharmacological profiling. This in turn will allow us to better understand how drugs influence the communication between functionally connected neural networks.

KW - microfluid drug testing

KW - drug discovery programs

KW - microfluidic array

UR - https://forum2016.fens.org/

M3 - Paper

ER -

MacKerron C, Robertson G, Bushell T, Zagnoni M. A novel microfluidic drug testing platform for studying communication between independent neural networks. 2016. Paper presented at 10th FENS (Federation of European Neuroscience Societies) Forum of Neuroscience 2016, Copenhagen, Denmark.