A novel microfluidic drug testing platform for studying communication between independent neural networks

Christopher MacKerron; Graham Robertson; Trevor Bushell; Michele Zagnoni

A novel microfluidic drug testing platform for studying communication between independent neural networks

Christopher MacKerron, Graham Robertson, Trevor Bushell, Michele Zagnoni

Research output: Contribution to conference › Paper › peer-review

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Abstract

Many in-vitro systems used during pre-clinical trials fail to recreate the biological complexity of the in-vivo neural microenvironment.Taking advantage of recent advances in microfluidic technology, we seek to develop a perfusion based drug discovery platform that is capable of high-throughput pharmacological profiling. This in turn will allow us to better understand how drugs influence the communication between functionally connected neural networks.

Original language	English
Publication status	Published - 2 Jul 2016
Event	10th FENS (Federation of European Neuroscience Societies) Forum of Neuroscience 2016 - Copenhagen, Denmark Duration: 2 Jul 2016 → 6 Jul 2016 Conference number: 10th

Conference

Conference	10th FENS (Federation of European Neuroscience Societies) Forum of Neuroscience 2016
Country/Territory	Denmark
City	Copenhagen
Period	2/07/16 → 6/07/16

Keywords

microfluid drug testing
drug discovery programs
microfluidic array

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MacKerron-etal-FENS-2016-A-novel-microfluidic-drug-testing-platform-for-studyingAccepted author manuscript, 210 KB

Cite this

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title = "A novel microfluidic drug testing platform for studying communication between independent neural networks",

abstract = "Many in-vitro systems used during pre-clinical trials fail to recreate the biological complexity of the in-vivo neural microenvironment.Taking advantage of recent advances in microfluidic technology, we seek to develop a perfusion based drug discovery platform that is capable of high-throughput pharmacological profiling. This in turn will allow us to better understand how drugs influence the communication between functionally connected neural networks.",

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A novel microfluidic drug testing platform for studying communication between independent neural networks. / MacKerron, Christopher; Robertson, Graham; Bushell, Trevor et al.
2016. Paper presented at 10th FENS (Federation of European Neuroscience Societies) Forum of Neuroscience 2016, Copenhagen, Denmark.

Research output: Contribution to conference › Paper › peer-review

TY - CONF

T1 - A novel microfluidic drug testing platform for studying communication between independent neural networks

AU - MacKerron, Christopher

AU - Robertson, Graham

AU - Bushell, Trevor

AU - Zagnoni, Michele

N1 - Conference code: 10th

PY - 2016/7/2

Y1 - 2016/7/2

N2 - Many in-vitro systems used during pre-clinical trials fail to recreate the biological complexity of the in-vivo neural microenvironment.Taking advantage of recent advances in microfluidic technology, we seek to develop a perfusion based drug discovery platform that is capable of high-throughput pharmacological profiling. This in turn will allow us to better understand how drugs influence the communication between functionally connected neural networks.

AB - Many in-vitro systems used during pre-clinical trials fail to recreate the biological complexity of the in-vivo neural microenvironment.Taking advantage of recent advances in microfluidic technology, we seek to develop a perfusion based drug discovery platform that is capable of high-throughput pharmacological profiling. This in turn will allow us to better understand how drugs influence the communication between functionally connected neural networks.

KW - microfluid drug testing

KW - drug discovery programs

KW - microfluidic array

UR - https://forum2016.fens.org/

M3 - Paper

T2 - 10th FENS (Federation of European Neuroscience Societies) Forum of Neuroscience 2016

Y2 - 2 July 2016 through 6 July 2016

ER -

A novel microfluidic drug testing platform for studying communication between independent neural networks

Abstract

Conference

Keywords

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