A novel 3D printed hollow microneedle microelectromechanical system for controlled, personalized transdermal drug delivery

Sofia N. Economidou; Md. Jasim Uddin; Manuel J. Marques; Dennis Douroumis; Wan Ting Sow; Huaqiong Li; Andrew Reid; James F.C. Windmill; Adrian Podoleanu

doi:10.1016/j.addma.2020.101815

A novel 3D printed hollow microneedle microelectromechanical system for controlled, personalized transdermal drug delivery

Sofia N. Economidou, Md. Jasim Uddin, Manuel J. Marques, Dennis Douroumis, Wan Ting Sow, Huaqiong Li, Andrew Reid, James F.C. Windmill, Adrian Podoleanu

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Abstract

The advancement of drug delivery devices is critical for the individualization of patient treatment and the improvement of healthcare. Here, we introduce the 3DMNMEMS, a novel device that combines 3D printing, microneedles (MNs) and Microelectromechanical Systems (MEMS), allowing versatile and controllable by the user transdermal drug delivery. Hollow MNs were designed and 3D printed using Stereolithography, followed by integrating into a MEMS. By employing advanced imaging techniques, we monitored the distribution of liquid delivered by the device within skin tissue in real time. In vivo testing revealed that the delivery of insulin using the 3DMNMEMS achieved improved glycemic control to diabetic animals compared to subcutaneous injections. These results demonstrated the potential of the 3DMNMEMS as a universal transdermal drug delivery system for personalized care.

Original language	English
Article number	101815
Number of pages	11
Journal	Additive Manufacturing
Volume	38
Early online date	30 Dec 2020
DOIs	https://doi.org/10.1016/j.addma.2020.101815
Publication status	Published - 28 Feb 2021

Keywords

microelectromechanical systems
3D printing
microneedles
optical coherence tomography
in vivo

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10.1016/j.addma.2020.101815

Economidou-etal-AM-2020-A-novel-3D-printed-hollow-microneedle-microelectromechanical-systemAccepted author manuscript, 530 KBLicence: CC BY-NC-ND 4.0

Cite this

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title = "A novel 3D printed hollow microneedle microelectromechanical system for controlled, personalized transdermal drug delivery",

abstract = "The advancement of drug delivery devices is critical for the individualization of patient treatment and the improvement of healthcare. Here, we introduce the 3DMNMEMS, a novel device that combines 3D printing, microneedles (MNs) and Microelectromechanical Systems (MEMS), allowing versatile and controllable by the user transdermal drug delivery. Hollow MNs were designed and 3D printed using Stereolithography, followed by integrating into a MEMS. By employing advanced imaging techniques, we monitored the distribution of liquid delivered by the device within skin tissue in real time. In vivo testing revealed that the delivery of insulin using the 3DMNMEMS achieved improved glycemic control to diabetic animals compared to subcutaneous injections. These results demonstrated the potential of the 3DMNMEMS as a universal transdermal drug delivery system for personalized care.",

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AU - Economidou, Sofia N.

AU - Uddin, Md. Jasim

AU - Marques, Manuel J.

AU - Douroumis, Dennis

AU - Sow, Wan Ting

AU - Li, Huaqiong

AU - Reid, Andrew

AU - Windmill, James F.C.

AU - Podoleanu, Adrian

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AB - The advancement of drug delivery devices is critical for the individualization of patient treatment and the improvement of healthcare. Here, we introduce the 3DMNMEMS, a novel device that combines 3D printing, microneedles (MNs) and Microelectromechanical Systems (MEMS), allowing versatile and controllable by the user transdermal drug delivery. Hollow MNs were designed and 3D printed using Stereolithography, followed by integrating into a MEMS. By employing advanced imaging techniques, we monitored the distribution of liquid delivered by the device within skin tissue in real time. In vivo testing revealed that the delivery of insulin using the 3DMNMEMS achieved improved glycemic control to diabetic animals compared to subcutaneous injections. These results demonstrated the potential of the 3DMNMEMS as a universal transdermal drug delivery system for personalized care.

KW - microelectromechanical systems

KW - 3D printing

KW - microneedles

KW - optical coherence tomography

KW - in vivo

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A novel 3D printed hollow microneedle microelectromechanical system for controlled, personalized transdermal drug delivery

Abstract

Keywords

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