A novel 3D printed hollow microneedle microelectromechanical system for controlled, personalized transdermal drug delivery

Sofia N. Economidou, Md. Jasim Uddin, Manuel J. Marques, Dennis Douroumis, Wan Ting Sow, Huaqiong Li, Andrew Reid, James F.C. Windmill, Adrian Podoleanu

Research output: Contribution to journalArticlepeer-review

Abstract

The advancement of drug delivery devices is critical for the individualization of patient treatment and the improvement of healthcare. Here, we introduce the 3DMNMEMS, a novel device that combines 3D printing, microneedles (MNs) and Microelectromechanical Systems (MEMS), allowing versatile and controllable by the user transdermal drug delivery. Hollow MNs were designed and 3D printed using Stereolithography, followed by integrating into a MEMS. By employing advanced imaging techniques, we monitored the distribution of liquid delivered by the device within skin tissue in real time. In vivo testing revealed that the delivery of insulin using the 3DMNMEMS achieved improved glycemic control to diabetic animals compared to subcutaneous injections. These results demonstrated the potential of the 3DMNMEMS as a universal transdermal drug delivery system for personalized care.
Original languageEnglish
Article number101815
Number of pages11
JournalAdditive Manufacturing
Volume38
Early online date30 Dec 2020
DOIs
Publication statusPublished - 28 Feb 2021

Keywords

  • microelectromechanical systems
  • 3D printing
  • microneedles
  • optical coherence tomography
  • in vivo

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