TY - JOUR
T1 - A novel 3D printed hollow microneedle microelectromechanical system for controlled, personalized transdermal drug delivery
AU - Economidou, Sofia N.
AU - Uddin, Md. Jasim
AU - Marques, Manuel J.
AU - Douroumis, Dennis
AU - Sow, Wan Ting
AU - Li, Huaqiong
AU - Reid, Andrew
AU - Windmill, James F.C.
AU - Podoleanu, Adrian
PY - 2021/2/28
Y1 - 2021/2/28
N2 - The advancement of drug delivery devices is critical for the individualization of patient treatment and the improvement of healthcare. Here, we introduce the 3DMNMEMS, a novel device that combines 3D printing, microneedles (MNs) and Microelectromechanical Systems (MEMS), allowing versatile and controllable by the user transdermal drug delivery. Hollow MNs were designed and 3D printed using Stereolithography, followed by integrating into a MEMS. By employing advanced imaging techniques, we monitored the distribution of liquid delivered by the device within skin tissue in real time. In vivo testing revealed that the delivery of insulin using the 3DMNMEMS achieved improved glycemic control to diabetic animals compared to subcutaneous injections. These results demonstrated the potential of the 3DMNMEMS as a universal transdermal drug delivery system for personalized care.
AB - The advancement of drug delivery devices is critical for the individualization of patient treatment and the improvement of healthcare. Here, we introduce the 3DMNMEMS, a novel device that combines 3D printing, microneedles (MNs) and Microelectromechanical Systems (MEMS), allowing versatile and controllable by the user transdermal drug delivery. Hollow MNs were designed and 3D printed using Stereolithography, followed by integrating into a MEMS. By employing advanced imaging techniques, we monitored the distribution of liquid delivered by the device within skin tissue in real time. In vivo testing revealed that the delivery of insulin using the 3DMNMEMS achieved improved glycemic control to diabetic animals compared to subcutaneous injections. These results demonstrated the potential of the 3DMNMEMS as a universal transdermal drug delivery system for personalized care.
KW - microelectromechanical systems
KW - 3D printing
KW - microneedles
KW - optical coherence tomography
KW - in vivo
U2 - 10.1016/j.addma.2020.101815
DO - 10.1016/j.addma.2020.101815
M3 - Article
SN - 2214-7810
VL - 38
JO - Additive Manufacturing
JF - Additive Manufacturing
M1 - 101815
ER -