A non-destructive method for quality control of the pellet distribution within a MUPS tablet by terahertz pulsed imaging

Anna Novikova, Daniel Markl, J. Axel Zeitler, Thomas Rades, Claudia S. Leopold

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Terahertz pulsed imaging (TPI) was applied to analyse the inner structure of multiple unit pellet system (MUPS) tablets. MUPS tablets containing different amounts of theophylline pellets coated with Eudragit® NE 30 D and with microcrystalline cellulose (MCC) as cushioning agent were analysed. The tablets were imaged by TPI and the results were compared to X-ray microtomography. The terahertz pulse beam propagates through the tablets and is back-reflected at the interface between the MCC matrix and the coated pellets within the tablet causing a peak in the terahertz waveform. Cross-section images of the tablets were extracted at different depths and parallel to the tablet faces from 3D terahertz data to visualise the surface-near structure of the MUPS tablets. The images of the surface-near structure of the MUPS tablets were compared to X-ray microtomography images at the same depths. The surface-near structure could be clearly resolved by TPI at depths between 24 and 152 μm below the tablet surface. An increasing amount of pellets within the MUPS tablets appears to slightly decrease the detectability of the pellets within the tablets by TPI. TPI was shown to be a non-destructive method for the detection of pellets within the tablets and could resolve structures thicker than 30 μm. In conclusion, a proof-of-concept was provided for TPI as a method of quality control for MUPS tablets.

LanguageEnglish
Pages549-555
Number of pages7
JournalEuropean Journal of Pharmaceutical Sciences
Volume111
Early online date19 Oct 2017
DOIs
Publication statusPublished - 1 Jan 2018

Fingerprint

Terahertz Imaging
Quality Control
Tablets
X-Ray Microtomography

Keywords

  • 3D mapping
  • MUPS tablets
  • pellet distribution analysis
  • quality control
  • spectroscopy
  • terahertz pulsed imaging

Cite this

@article{738cbb2310ef47d2a4c53ccc8cf66990,
title = "A non-destructive method for quality control of the pellet distribution within a MUPS tablet by terahertz pulsed imaging",
abstract = "Terahertz pulsed imaging (TPI) was applied to analyse the inner structure of multiple unit pellet system (MUPS) tablets. MUPS tablets containing different amounts of theophylline pellets coated with Eudragit{\circledR} NE 30 D and with microcrystalline cellulose (MCC) as cushioning agent were analysed. The tablets were imaged by TPI and the results were compared to X-ray microtomography. The terahertz pulse beam propagates through the tablets and is back-reflected at the interface between the MCC matrix and the coated pellets within the tablet causing a peak in the terahertz waveform. Cross-section images of the tablets were extracted at different depths and parallel to the tablet faces from 3D terahertz data to visualise the surface-near structure of the MUPS tablets. The images of the surface-near structure of the MUPS tablets were compared to X-ray microtomography images at the same depths. The surface-near structure could be clearly resolved by TPI at depths between 24 and 152 μm below the tablet surface. An increasing amount of pellets within the MUPS tablets appears to slightly decrease the detectability of the pellets within the tablets by TPI. TPI was shown to be a non-destructive method for the detection of pellets within the tablets and could resolve structures thicker than 30 μm. In conclusion, a proof-of-concept was provided for TPI as a method of quality control for MUPS tablets.",
keywords = "3D mapping, MUPS tablets, pellet distribution analysis, quality control, spectroscopy, terahertz pulsed imaging",
author = "Anna Novikova and Daniel Markl and Zeitler, {J. Axel} and Thomas Rades and Leopold, {Claudia S.}",
year = "2018",
month = "1",
day = "1",
doi = "10.1016/j.ejps.2017.10.029",
language = "English",
volume = "111",
pages = "549--555",
journal = "European Journal of Pharmaceutical Sciences",
issn = "0928-0987",

}

A non-destructive method for quality control of the pellet distribution within a MUPS tablet by terahertz pulsed imaging. / Novikova, Anna; Markl, Daniel; Zeitler, J. Axel; Rades, Thomas; Leopold, Claudia S.

In: European Journal of Pharmaceutical Sciences, Vol. 111, 01.01.2018, p. 549-555.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A non-destructive method for quality control of the pellet distribution within a MUPS tablet by terahertz pulsed imaging

AU - Novikova, Anna

AU - Markl, Daniel

AU - Zeitler, J. Axel

AU - Rades, Thomas

AU - Leopold, Claudia S.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Terahertz pulsed imaging (TPI) was applied to analyse the inner structure of multiple unit pellet system (MUPS) tablets. MUPS tablets containing different amounts of theophylline pellets coated with Eudragit® NE 30 D and with microcrystalline cellulose (MCC) as cushioning agent were analysed. The tablets were imaged by TPI and the results were compared to X-ray microtomography. The terahertz pulse beam propagates through the tablets and is back-reflected at the interface between the MCC matrix and the coated pellets within the tablet causing a peak in the terahertz waveform. Cross-section images of the tablets were extracted at different depths and parallel to the tablet faces from 3D terahertz data to visualise the surface-near structure of the MUPS tablets. The images of the surface-near structure of the MUPS tablets were compared to X-ray microtomography images at the same depths. The surface-near structure could be clearly resolved by TPI at depths between 24 and 152 μm below the tablet surface. An increasing amount of pellets within the MUPS tablets appears to slightly decrease the detectability of the pellets within the tablets by TPI. TPI was shown to be a non-destructive method for the detection of pellets within the tablets and could resolve structures thicker than 30 μm. In conclusion, a proof-of-concept was provided for TPI as a method of quality control for MUPS tablets.

AB - Terahertz pulsed imaging (TPI) was applied to analyse the inner structure of multiple unit pellet system (MUPS) tablets. MUPS tablets containing different amounts of theophylline pellets coated with Eudragit® NE 30 D and with microcrystalline cellulose (MCC) as cushioning agent were analysed. The tablets were imaged by TPI and the results were compared to X-ray microtomography. The terahertz pulse beam propagates through the tablets and is back-reflected at the interface between the MCC matrix and the coated pellets within the tablet causing a peak in the terahertz waveform. Cross-section images of the tablets were extracted at different depths and parallel to the tablet faces from 3D terahertz data to visualise the surface-near structure of the MUPS tablets. The images of the surface-near structure of the MUPS tablets were compared to X-ray microtomography images at the same depths. The surface-near structure could be clearly resolved by TPI at depths between 24 and 152 μm below the tablet surface. An increasing amount of pellets within the MUPS tablets appears to slightly decrease the detectability of the pellets within the tablets by TPI. TPI was shown to be a non-destructive method for the detection of pellets within the tablets and could resolve structures thicker than 30 μm. In conclusion, a proof-of-concept was provided for TPI as a method of quality control for MUPS tablets.

KW - 3D mapping

KW - MUPS tablets

KW - pellet distribution analysis

KW - quality control

KW - spectroscopy

KW - terahertz pulsed imaging

UR - http://www.scopus.com/inward/record.url?scp=85032884684&partnerID=8YFLogxK

U2 - 10.1016/j.ejps.2017.10.029

DO - 10.1016/j.ejps.2017.10.029

M3 - Article

VL - 111

SP - 549

EP - 555

JO - European Journal of Pharmaceutical Sciences

T2 - European Journal of Pharmaceutical Sciences

JF - European Journal of Pharmaceutical Sciences

SN - 0928-0987

ER -