A new tetrahydrofuran derivative from the endophytic fungus chaetomium sp isolated from otanthus maritimus

A.H. Aly; A. Debbab; R.A. Edrada-Ebel; V. Wray; W.E.G. Muller; W.H. Lin; R. Ebel; P. Proksch; BMBF (Funder); MOST (Funder)

A new tetrahydrofuran derivative from the endophytic fungus chaetomium sp isolated from otanthus maritimus

A.H. Aly, A. Debbab, R.A. Edrada-Ebel, V. Wray, W.E.G. Muller, W.H. Lin, R. Ebel, P. Proksch, BMBF (Funder), MOST (Funder)

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

A hitherto unidentified endophytic strain of the genus Chaetomium, isolated from the medicinal plant Otanthus maritimus, yielded a new tetrahydrofuran derivative, aureonitolic acid (1), along with 5 known natural products, 2-6. The structure of 1 was determined by extensive spectroscopic analysis and comparison with reported data. Extracts of the fungus, grown either in liquid culture or on solid rice media, exhibited considerable cytotoxic activity when tested in vitro against L5178Y mouse lymphoma cells. Compounds 2 and 6 showed significant growth inhibition against L5178Y cells with EC50, values of 7.0 and 2.7 mu g/mL, respectively, whereas 1 was inactive.

Original language	English
Pages (from-to)	350-354
Number of pages	4
Journal	Zeitschrift fur Naturforschung C
Volume	64
Issue number	5-6
Publication status	Published - May 2009

Keywords

endophytes
chaetomium
natural products
structure elucidation

Cite this

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title = "A new tetrahydrofuran derivative from the endophytic fungus chaetomium sp isolated from otanthus maritimus",

abstract = "A hitherto unidentified endophytic strain of the genus Chaetomium, isolated from the medicinal plant Otanthus maritimus, yielded a new tetrahydrofuran derivative, aureonitolic acid (1), along with 5 known natural products, 2-6. The structure of 1 was determined by extensive spectroscopic analysis and comparison with reported data. Extracts of the fungus, grown either in liquid culture or on solid rice media, exhibited considerable cytotoxic activity when tested in vitro against L5178Y mouse lymphoma cells. Compounds 2 and 6 showed significant growth inhibition against L5178Y cells with EC50, values of 7.0 and 2.7 mu g/mL, respectively, whereas 1 was inactive.",

keywords = "endophytes, chaetomium, natural products, structure elucidation",

author = "A.H. Aly and A. Debbab and R.A. Edrada-Ebel and V. Wray and W.E.G. Muller and W.H. Lin and R. Ebel and P. Proksch and \{BMBF (Funder)\} and \{MOST (Funder)\}",

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T1 - A new tetrahydrofuran derivative from the endophytic fungus chaetomium sp isolated from otanthus maritimus

AU - Aly, A.H.

AU - Debbab, A.

AU - Edrada-Ebel, R.A.

AU - Wray, V.

AU - Muller, W.E.G.

AU - Lin, W.H.

AU - Ebel, R.

AU - Proksch, P.

AU - BMBF (Funder)

AU - MOST (Funder)

PY - 2009/5

Y1 - 2009/5

N2 - A hitherto unidentified endophytic strain of the genus Chaetomium, isolated from the medicinal plant Otanthus maritimus, yielded a new tetrahydrofuran derivative, aureonitolic acid (1), along with 5 known natural products, 2-6. The structure of 1 was determined by extensive spectroscopic analysis and comparison with reported data. Extracts of the fungus, grown either in liquid culture or on solid rice media, exhibited considerable cytotoxic activity when tested in vitro against L5178Y mouse lymphoma cells. Compounds 2 and 6 showed significant growth inhibition against L5178Y cells with EC50, values of 7.0 and 2.7 mu g/mL, respectively, whereas 1 was inactive.

AB - A hitherto unidentified endophytic strain of the genus Chaetomium, isolated from the medicinal plant Otanthus maritimus, yielded a new tetrahydrofuran derivative, aureonitolic acid (1), along with 5 known natural products, 2-6. The structure of 1 was determined by extensive spectroscopic analysis and comparison with reported data. Extracts of the fungus, grown either in liquid culture or on solid rice media, exhibited considerable cytotoxic activity when tested in vitro against L5178Y mouse lymphoma cells. Compounds 2 and 6 showed significant growth inhibition against L5178Y cells with EC50, values of 7.0 and 2.7 mu g/mL, respectively, whereas 1 was inactive.

KW - endophytes

KW - chaetomium

KW - natural products

KW - structure elucidation

UR - http://www.znaturforsch.com/c.htm

M3 - Article

SN - 0939-5075

VL - 64

SP - 350

EP - 354

JO - Zeitschrift fur Naturforschung C

JF - Zeitschrift fur Naturforschung C

IS - 5-6

ER -

A new tetrahydrofuran derivative from the endophytic fungus chaetomium sp isolated from otanthus maritimus

Abstract

Keywords

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