TY - JOUR
T1 - A new tetrahydrofuran derivative from the endophytic fungus chaetomium sp isolated from otanthus maritimus
AU - Aly, A.H.
AU - Debbab, A.
AU - Edrada-Ebel, R.A.
AU - Wray, V.
AU - Muller, W.E.G.
AU - Lin, W.H.
AU - Ebel, R.
AU - Proksch, P.
AU - BMBF (Funder)
AU - MOST (Funder)
PY - 2009/5
Y1 - 2009/5
N2 - A hitherto unidentified endophytic strain of the genus Chaetomium, isolated from the medicinal plant Otanthus maritimus, yielded a new tetrahydrofuran derivative, aureonitolic acid (1), along with 5 known natural products, 2-6. The structure of 1 was determined by extensive spectroscopic analysis and comparison with reported data. Extracts of the fungus, grown either in liquid culture or on solid rice media, exhibited considerable cytotoxic activity when tested in vitro against L5178Y mouse lymphoma cells. Compounds 2 and 6 showed significant growth inhibition against L5178Y cells with EC50, values of 7.0 and 2.7 mu g/mL, respectively, whereas 1 was inactive.
AB - A hitherto unidentified endophytic strain of the genus Chaetomium, isolated from the medicinal plant Otanthus maritimus, yielded a new tetrahydrofuran derivative, aureonitolic acid (1), along with 5 known natural products, 2-6. The structure of 1 was determined by extensive spectroscopic analysis and comparison with reported data. Extracts of the fungus, grown either in liquid culture or on solid rice media, exhibited considerable cytotoxic activity when tested in vitro against L5178Y mouse lymphoma cells. Compounds 2 and 6 showed significant growth inhibition against L5178Y cells with EC50, values of 7.0 and 2.7 mu g/mL, respectively, whereas 1 was inactive.
KW - endophytes
KW - chaetomium
KW - natural products
KW - structure elucidation
UR - http://www.znaturforsch.com/c.htm
M3 - Article
SN - 0939-5075
VL - 64
SP - 350
EP - 354
JO - Zeitschrift fur Naturforschung C
JF - Zeitschrift fur Naturforschung C
IS - 5-6
ER -