A new platinum anticancer drug forms a highly stereoselective adduct with duplex DNA

Yu Chen; John Parkinson; Zijian Guo; Tom Brown; Peter J. Sadler

doi:10.1002/(SICI)1521-3773(19990712)38:13/14<2060::AID-ANIE2060>3.0.CO;2-J

A new platinum anticancer drug forms a highly stereoselective adduct with duplex DNA

Yu Chen
, John Parkinson
, Zijian Guo
, Tom Brown
, Peter J. Sadler

Pure And Applied Chemistry

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

The alignment of the 2-picoline ligand within the major groove contributes to the formation of a highly stereoselective GG intrastrand bischelate between the new anticancer drug cis-[PtCl₂(NH₃)(2-picoline)] and a 14-mer DNA duplex (see schematic representation).

Original language	English
Pages (from-to)	2060-2063
Number of pages	4
Journal	Angewandte Chemie International Edition
Volume	38
Issue number	13-14
DOIs	https://doi.org/10.1002/(SICI)1521-3773(19990712)38:13/14<2060::AID-ANIE2060>3.0.CO;2-J
Publication status	Published - 12 Jul 1999

Keywords

anticancer drugs
platinum
duplex DNA

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10.1002/(SICI)1521-3773(19990712)38:13/14<2060::AID-ANIE2060>3.0.CO;2-J

Cite this

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title = "A new platinum anticancer drug forms a highly stereoselective adduct with duplex DNA",

abstract = "The alignment of the 2-picoline ligand within the major groove contributes to the formation of a highly stereoselective GG intrastrand bischelate between the new anticancer drug cis-[PtCl2(NH3)(2-picoline)] and a 14-mer DNA duplex (see schematic representation).",

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AU - Chen, Yu

AU - Parkinson, John

AU - Guo, Zijian

AU - Brown, Tom

AU - Sadler, Peter J.

PY - 1999/7/12

Y1 - 1999/7/12

N2 - The alignment of the 2-picoline ligand within the major groove contributes to the formation of a highly stereoselective GG intrastrand bischelate between the new anticancer drug cis-[PtCl2(NH3)(2-picoline)] and a 14-mer DNA duplex (see schematic representation).

AB - The alignment of the 2-picoline ligand within the major groove contributes to the formation of a highly stereoselective GG intrastrand bischelate between the new anticancer drug cis-[PtCl2(NH3)(2-picoline)] and a 14-mer DNA duplex (see schematic representation).

KW - anticancer drugs

KW - platinum

KW - duplex DNA

U2 - 10.1002/(SICI)1521-3773(19990712)38:13/14<2060::AID-ANIE2060>3.0.CO;2-J

DO - 10.1002/(SICI)1521-3773(19990712)38:13/14<2060::AID-ANIE2060>3.0.CO;2-J

M3 - Article

SN - 1433-7851

VL - 38

SP - 2060

EP - 2063

JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

IS - 13-14

ER -

A new platinum anticancer drug forms a highly stereoselective adduct with duplex DNA

Abstract

Keywords

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