A new platinum anticancer drug forms a highly stereoselective adduct with duplex DNA

Yu Chen, John Parkinson, Zijian Guo, Tom Brown, Peter J. Sadler

Research output: Contribution to journalArticlepeer-review

48 Citations (Scopus)

Abstract

The alignment of the 2-picoline ligand within the major groove contributes to the formation of a highly stereoselective GG intrastrand bischelate between the new anticancer drug cis-[PtCl2(NH3)(2-picoline)] and a 14-mer DNA duplex (see schematic representation).
Original languageEnglish
Pages (from-to)2060-2063
Number of pages4
JournalAngewandte Chemie International Edition
Volume38
Issue number13-14
DOIs
Publication statusPublished - 12 Jul 1999

Keywords

  • anticancer drugs
  • platinum
  • duplex DNA

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