A new molecularly imprinted polymer for the selective extraction of naproxen from urine samples by solid-phase extraction

E. Caro; R.M. Marce; P.A.G. Cormack; D.C. Sherrington; F. Borrull

doi:10.1016/j.jchromb.2004.09.019

A new molecularly imprinted polymer for the selective extraction of naproxen from urine samples by solid-phase extraction

E. Caro, R.M. Marce, P.A.G. Cormack, D.C. Sherrington, F. Borrull

Pure And Applied Chemistry

Research output: Contribution to journal › Article › peer-review

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Abstract

A non-covalent molecularly imprinted polymer (MIP) was synthesised using naproxen (a non-steroidal, anti-inflammatory drug (NSAID)) as a template molecule. The NIT was chromatographically evaluated to confirm the imprinting effect, and was then applied as a selective sorbent in solid-phase extraction (SPE) to selectively extract naproxen. After this study, the NIT was used to extract naproxen from urine samples; it was demonstrated that by applying a selective washing step with acetonitrile (ACN) the compounds in the sample that were structurally related to naproxen could be eliminated.

Original language	English
Pages (from-to)	137-143
Number of pages	6
Journal	Journal of Chromatography B
Volume	813
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jchromb.2004.09.019
Publication status	Published - 25 Dec 2004

Keywords

molecularly imprinted polymer
solid-phase extraction
naproxen
human urine samples

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jchromb.2004.09.019

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title = "A new molecularly imprinted polymer for the selective extraction of naproxen from urine samples by solid-phase extraction",

abstract = "A non-covalent molecularly imprinted polymer (MIP) was synthesised using naproxen (a non-steroidal, anti-inflammatory drug (NSAID)) as a template molecule. The NIT was chromatographically evaluated to confirm the imprinting effect, and was then applied as a selective sorbent in solid-phase extraction (SPE) to selectively extract naproxen. After this study, the NIT was used to extract naproxen from urine samples; it was demonstrated that by applying a selective washing step with acetonitrile (ACN) the compounds in the sample that were structurally related to naproxen could be eliminated.",

keywords = "molecularly imprinted polymer, solid-phase extraction, naproxen, human urine samples",

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T1 - A new molecularly imprinted polymer for the selective extraction of naproxen from urine samples by solid-phase extraction

AU - Caro, E.

AU - Marce, R.M.

AU - Cormack, P.A.G.

AU - Sherrington, D.C.

AU - Borrull, F.

PY - 2004/12/25

Y1 - 2004/12/25

N2 - A non-covalent molecularly imprinted polymer (MIP) was synthesised using naproxen (a non-steroidal, anti-inflammatory drug (NSAID)) as a template molecule. The NIT was chromatographically evaluated to confirm the imprinting effect, and was then applied as a selective sorbent in solid-phase extraction (SPE) to selectively extract naproxen. After this study, the NIT was used to extract naproxen from urine samples; it was demonstrated that by applying a selective washing step with acetonitrile (ACN) the compounds in the sample that were structurally related to naproxen could be eliminated.

AB - A non-covalent molecularly imprinted polymer (MIP) was synthesised using naproxen (a non-steroidal, anti-inflammatory drug (NSAID)) as a template molecule. The NIT was chromatographically evaluated to confirm the imprinting effect, and was then applied as a selective sorbent in solid-phase extraction (SPE) to selectively extract naproxen. After this study, the NIT was used to extract naproxen from urine samples; it was demonstrated that by applying a selective washing step with acetonitrile (ACN) the compounds in the sample that were structurally related to naproxen could be eliminated.

KW - molecularly imprinted polymer

KW - solid-phase extraction

KW - naproxen

KW - human urine samples

UR - http://dx.doi.org/10.1016/j.jchromb.2004.09.019

U2 - 10.1016/j.jchromb.2004.09.019

DO - 10.1016/j.jchromb.2004.09.019

M3 - Article

SN - 1570-0232

VL - 813

SP - 137

EP - 143

JO - Journal of Chromatography B

JF - Journal of Chromatography B

IS - 1-2

ER -

A new molecularly imprinted polymer for the selective extraction of naproxen from urine samples by solid-phase extraction

Abstract

Keywords

UN SDGs

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