TY - JOUR
T1 - A new molecularly imprinted polymer for the selective extraction of naproxen from urine samples by solid-phase extraction
AU - Caro, E.
AU - Marce, R.M.
AU - Cormack, P.A.G.
AU - Sherrington, D.C.
AU - Borrull, F.
PY - 2004/12/25
Y1 - 2004/12/25
N2 - A non-covalent molecularly imprinted polymer (MIP) was synthesised using naproxen (a non-steroidal, anti-inflammatory drug (NSAID)) as a template molecule. The NIT was chromatographically evaluated to confirm the imprinting effect, and was then applied as a selective sorbent in solid-phase extraction (SPE) to selectively extract naproxen. After this study, the NIT was used to extract naproxen from urine samples; it was demonstrated that by applying a selective washing step with acetonitrile (ACN) the compounds in the sample that were structurally related to naproxen could be eliminated.
AB - A non-covalent molecularly imprinted polymer (MIP) was synthesised using naproxen (a non-steroidal, anti-inflammatory drug (NSAID)) as a template molecule. The NIT was chromatographically evaluated to confirm the imprinting effect, and was then applied as a selective sorbent in solid-phase extraction (SPE) to selectively extract naproxen. After this study, the NIT was used to extract naproxen from urine samples; it was demonstrated that by applying a selective washing step with acetonitrile (ACN) the compounds in the sample that were structurally related to naproxen could be eliminated.
KW - molecularly imprinted polymer
KW - solid-phase extraction
KW - naproxen
KW - human urine samples
UR - http://dx.doi.org/10.1016/j.jchromb.2004.09.019
U2 - 10.1016/j.jchromb.2004.09.019
DO - 10.1016/j.jchromb.2004.09.019
M3 - Article
SN - 1570-0232
VL - 813
SP - 137
EP - 143
JO - Journal of Chromatography B
JF - Journal of Chromatography B
IS - 1-2
ER -
