A new molecularly imprinted polymer for the selective extraction of naproxen from urine samples by solid-phase extraction

E. Caro, R.M. Marce, P.A.G. Cormack, D.C. Sherrington, F. Borrull

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

A non-covalent molecularly imprinted polymer (MIP) was synthesised using naproxen (a non-steroidal, anti-inflammatory drug (NSAID)) as a template molecule. The NIT was chromatographically evaluated to confirm the imprinting effect, and was then applied as a selective sorbent in solid-phase extraction (SPE) to selectively extract naproxen. After this study, the NIT was used to extract naproxen from urine samples; it was demonstrated that by applying a selective washing step with acetonitrile (ACN) the compounds in the sample that were structurally related to naproxen could be eliminated.
LanguageEnglish
Pages137-143
Number of pages6
JournalJournal of Chromatography B
Volume813
Issue number1-2
DOIs
Publication statusPublished - 25 Dec 2004

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Naproxen
Solid Phase Extraction
Polymers
Urine
Sorbents
Washing
Anti-Inflammatory Agents
Molecules
Pharmaceutical Preparations

Keywords

  • molecularly imprinted polymer
  • solid-phase extraction
  • naproxen
  • human urine samples

Cite this

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A new molecularly imprinted polymer for the selective extraction of naproxen from urine samples by solid-phase extraction. / Caro, E.; Marce, R.M.; Cormack, P.A.G.; Sherrington, D.C.; Borrull, F.

In: Journal of Chromatography B , Vol. 813, No. 1-2, 25.12.2004, p. 137-143.

Research output: Contribution to journalArticle

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AU - Caro, E.

AU - Marce, R.M.

AU - Cormack, P.A.G.

AU - Sherrington, D.C.

AU - Borrull, F.

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KW - molecularly imprinted polymer

KW - solid-phase extraction

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KW - human urine samples

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