A non-covalent molecularly imprinted polymer (MIP) was synthesised using naproxen (a non-steroidal, anti-inflammatory drug (NSAID)) as a template molecule. The NIT was chromatographically evaluated to confirm the imprinting effect, and was then applied as a selective sorbent in solid-phase extraction (SPE) to selectively extract naproxen. After this study, the NIT was used to extract naproxen from urine samples; it was demonstrated that by applying a selective washing step with acetonitrile (ACN) the compounds in the sample that were structurally related to naproxen could be eliminated.
- molecularly imprinted polymer
- solid-phase extraction
- human urine samples
Caro, E., Marce, R. M., Cormack, P. A. G., Sherrington, D. C., & Borrull, F. (2004). A new molecularly imprinted polymer for the selective extraction of naproxen from urine samples by solid-phase extraction. Journal of Chromatography B , 813(1-2), 137-143. https://doi.org/10.1016/j.jchromb.2004.09.019