A new drug vehicle - lipid coated biodegradable nanoparticles

J. Schäfer; Johannes Sitterberg; C. Ehrhardt; M.N.V. Ravi Kumar; Udo Bakowsky

doi:10.4028/www.scientific.net/AST.57.148

A new drug vehicle - lipid coated biodegradable nanoparticles

J. Schäfer, Johannes Sitterberg, C. Ehrhardt, M.N.V. Ravi Kumar, Udo Bakowsky

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

The preparation and charactersiation of novel lipid coated PLGA nanoparticles was investigated in the presented study. The size of the pure nanoparticles could be adjusted in dependence on the stabilizer content. The supported lipid bilayer surrounding the nanoparticles was formed by the liposome spreading technique. The Lipid- coated nanoparticles were characterised using Photon Correlation Spectroscopy (PCS) and atomic force microscopy (AFM) investigations. The bioadhesive properties was proofed in a cell culture model.

Original language	English
Pages (from-to)	148-153
Number of pages	5
Journal	Advances in Science and Technology
Volume	57
DOIs	https://doi.org/10.4028/www.scientific.net/AST.57.148
Publication status	Published - Sept 2008

Keywords

atomic force microscopy
biodegradable nanoparticles
lipid coating
PLGA

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10.4028/www.scientific.net/AST.57.148

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abstract = "The preparation and charactersiation of novel lipid coated PLGA nanoparticles was investigated in the presented study. The size of the pure nanoparticles could be adjusted in dependence on the stabilizer content. The supported lipid bilayer surrounding the nanoparticles was formed by the liposome spreading technique. The Lipid- coated nanoparticles were characterised using Photon Correlation Spectroscopy (PCS) and atomic force microscopy (AFM) investigations. The bioadhesive properties was proofed in a cell culture model.",

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AU - Sitterberg, Johannes

AU - Ehrhardt, C.

AU - Kumar, M.N.V. Ravi

AU - Bakowsky, Udo

PY - 2008/9

Y1 - 2008/9

N2 - The preparation and charactersiation of novel lipid coated PLGA nanoparticles was investigated in the presented study. The size of the pure nanoparticles could be adjusted in dependence on the stabilizer content. The supported lipid bilayer surrounding the nanoparticles was formed by the liposome spreading technique. The Lipid- coated nanoparticles were characterised using Photon Correlation Spectroscopy (PCS) and atomic force microscopy (AFM) investigations. The bioadhesive properties was proofed in a cell culture model.

AB - The preparation and charactersiation of novel lipid coated PLGA nanoparticles was investigated in the presented study. The size of the pure nanoparticles could be adjusted in dependence on the stabilizer content. The supported lipid bilayer surrounding the nanoparticles was formed by the liposome spreading technique. The Lipid- coated nanoparticles were characterised using Photon Correlation Spectroscopy (PCS) and atomic force microscopy (AFM) investigations. The bioadhesive properties was proofed in a cell culture model.

KW - atomic force microscopy

KW - biodegradable nanoparticles

KW - lipid coating

KW - PLGA

UR - http://dx.doi.org/10.4028/www.scientific.net/AST.57.148

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DO - 10.4028/www.scientific.net/AST.57.148

M3 - Article

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SP - 148

EP - 153

JO - Advances in Science and Technology

JF - Advances in Science and Technology

ER -

A new drug vehicle - lipid coated biodegradable nanoparticles

Abstract

Keywords

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