TY - JOUR
T1 - A new drug vehicle - lipid coated biodegradable nanoparticles
AU - Schäfer, J.
AU - Sitterberg, Johannes
AU - Ehrhardt, C.
AU - Kumar, M.N.V. Ravi
AU - Bakowsky, Udo
PY - 2008/9
Y1 - 2008/9
N2 - The preparation and charactersiation of novel lipid coated PLGA nanoparticles was investigated in the presented study. The size of the pure nanoparticles could be adjusted in dependence on the stabilizer content. The supported lipid bilayer surrounding the nanoparticles was formed by the liposome spreading technique. The Lipid- coated nanoparticles were characterised using Photon Correlation Spectroscopy (PCS) and atomic force microscopy (AFM) investigations. The bioadhesive properties was proofed in a cell culture model.
AB - The preparation and charactersiation of novel lipid coated PLGA nanoparticles was investigated in the presented study. The size of the pure nanoparticles could be adjusted in dependence on the stabilizer content. The supported lipid bilayer surrounding the nanoparticles was formed by the liposome spreading technique. The Lipid- coated nanoparticles were characterised using Photon Correlation Spectroscopy (PCS) and atomic force microscopy (AFM) investigations. The bioadhesive properties was proofed in a cell culture model.
KW - atomic force microscopy
KW - biodegradable nanoparticles
KW - lipid coating
KW - PLGA
UR - http://dx.doi.org/10.4028/www.scientific.net/AST.57.148
U2 - 10.4028/www.scientific.net/AST.57.148
DO - 10.4028/www.scientific.net/AST.57.148
M3 - Article
VL - 57
SP - 148
EP - 153
JO - Advances in Science and Technology
JF - Advances in Science and Technology
SN - 1662-8969
ER -