A new bioactive sesquiterpenoid quinone from the mediterranean sea marine sponge Dysidea avara

Ashraf Nageeb El-Sayed Hamed, Wim Wätjen, Roland Schmitz, Yvonni Chovolou, Ruangelie Edrada-Ebel, Diaa T A Youssef, Mohammed Salah Kamel, Peter Proksch

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12 Citations (Scopus)


Investigation of the marine sponge Dysidea avara, family Dysideidae, afforded a new sesquiterpene (-)-N-methylmelemeleone-A (5), in addition to four known sesquiterpenes (+)-avarol (1), (+)-avarone (2), (-)-3′- methylaminoavarone (3) and (-)-4′-methylaminoavarone (4). The structure elucidation of compound 5 was based on 1D and 2D NMR spectroscopic, and HR-MS studies, as well as by comparison with the literature. Cytotoxicity, protein kinase inhibition, inhibition of NFκB-activity and insecticidal activity were evaluated for the isolated compounds.

Original languageEnglish
Pages (from-to)289-292
Number of pages4
JournalNatural Product Communications
Issue number3
Publication statusPublished - 9 Apr 2013


  • cytotoxicity
  • dysidea avara
  • insecticidial activity
  • NF-κB
  • protein kinase inhibition
  • sesquiterpene

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