TY - JOUR
T1 - A new bioactive sesquiterpenoid quinone from the mediterranean sea marine sponge Dysidea avara
AU - El-Sayed Hamed, Ashraf Nageeb
AU - Wätjen, Wim
AU - Schmitz, Roland
AU - Chovolou, Yvonni
AU - Edrada-Ebel, Ruangelie
AU - Youssef, Diaa T A
AU - Kamel, Mohammed Salah
AU - Proksch, Peter
PY - 2013/4/9
Y1 - 2013/4/9
N2 - Investigation of the marine sponge Dysidea avara, family Dysideidae, afforded a new sesquiterpene (-)-N-methylmelemeleone-A (5), in addition to four known sesquiterpenes (+)-avarol (1), (+)-avarone (2), (-)-3′- methylaminoavarone (3) and (-)-4′-methylaminoavarone (4). The structure elucidation of compound 5 was based on 1D and 2D NMR spectroscopic, and HR-MS studies, as well as by comparison with the literature. Cytotoxicity, protein kinase inhibition, inhibition of NFκB-activity and insecticidal activity were evaluated for the isolated compounds.
AB - Investigation of the marine sponge Dysidea avara, family Dysideidae, afforded a new sesquiterpene (-)-N-methylmelemeleone-A (5), in addition to four known sesquiterpenes (+)-avarol (1), (+)-avarone (2), (-)-3′- methylaminoavarone (3) and (-)-4′-methylaminoavarone (4). The structure elucidation of compound 5 was based on 1D and 2D NMR spectroscopic, and HR-MS studies, as well as by comparison with the literature. Cytotoxicity, protein kinase inhibition, inhibition of NFκB-activity and insecticidal activity were evaluated for the isolated compounds.
KW - cytotoxicity
KW - dysidea avara
KW - insecticidial activity
KW - NF-κB
KW - protein kinase inhibition
KW - sesquiterpene
UR - http://www.scopus.com/inward/record.url?scp=84875772270&partnerID=8YFLogxK
M3 - Article
C2 - 23678793
AN - SCOPUS:84875772270
SN - 1934-578X
VL - 8
SP - 289
EP - 292
JO - Natural Product Communications
JF - Natural Product Communications
IS - 3
ER -
