Diels-Alder cycloaddition has been used to add a benzotriazole azo dye to a diene tagged oligonucleotide to generate unique SERRS signals at 10 attomoles.
- resonance raman-scattering
- surface-enhanced raman
- labeled dna
Fruk, L., Grondin, A., Smith, W. E., & Graham, D. (2002). A new approach to oligonucleotide labelling using Diels-Alder cycloadditions and detection by SERRS. Chemical Communications (London), 2002(18), 2100-2101. https://doi.org/10.1039/b204790j