A multicomponent route to functionalized amides and oxazolidinones

Christopher G. McPherson, Alasdair K. Cooper, Andrius Bubliauskas, Paul Mulrainey, Craig Jamieson, Allan J. B. Watson

Research output: Contribution to journalLetter

1 Citation (Scopus)

Abstract

An organobase-mediated, multicomponent reaction of unactivated esters, epoxides, and amines is reported, furnishing functionalized amide derivatives. A wide range of substrates are tolerated under the reaction conditions, including chiral epoxides, which react with no erosion of enantiopurity. Facile modification of the method, through replacing the ester derivative with dimethyl carbonate, enables access to the corresponding oxazolidinone derivatives.
LanguageEnglish
Number of pages4
JournalOrganic Letters
DOIs
Publication statusPublished - 1 Dec 2017

Fingerprint

Oxazolidinones
epoxy compounds
Epoxy Compounds
Amides
amides
esters
Esters
routes
Derivatives
erosion
Amines
carbonates
amines
Erosion
Substrates
methyl carbonate

Keywords

  • esters
  • epoxides
  • amines

Cite this

McPherson, Christopher G. ; Cooper, Alasdair K. ; Bubliauskas, Andrius ; Mulrainey, Paul ; Jamieson, Craig ; Watson, Allan J. B. / A multicomponent route to functionalized amides and oxazolidinones. In: Organic Letters. 2017.
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A multicomponent route to functionalized amides and oxazolidinones. / McPherson, Christopher G.; Cooper, Alasdair K.; Bubliauskas, Andrius; Mulrainey, Paul; Jamieson, Craig; Watson, Allan J. B.

In: Organic Letters, 01.12.2017.

Research output: Contribution to journalLetter

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AU - Bubliauskas, Andrius

AU - Mulrainey, Paul

AU - Jamieson, Craig

AU - Watson, Allan J. B.

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