Abstract
Objectives: In line with the recent global action plan for antimicrobial resistance, this is the first time such a comprehensive antimicrobial point prevalence survey has been undertaken in Pakistan, the sixth most populous country. Methods: This point prevalence survey (PPS) was conducted in 13 hospitals among 7 different cities of Pakistan. The survey included all inpatients receiving an antibiotic on the day of PPS. A web-based application was used for data entry, validation, and reporting as designed by the University of Antwerp (www.global-pps.com). Results: Out of 1954 patients, 1516 (77.6%) were treated with antibiotics. The top three most reported indications for antibiotic use were prophylaxis for obstetrics or gynaecological indications (16.5%), gastrointestinal indications (12.6%) and lower respiratory tract infections (12.0%). The top three most commonly prescribed antibiotics were ceftriaxone (35.0%), metronidazole (16.0%) and ciprofloxacin (6.0%). Out of the total indications, 34.2% of antibiotics were prescribed for community-acquired infections (CAI), 5.9% for healthcare-associated infections (HAI), and 57.4% for either surgical or medical prophylaxis. Of the total use for surgical prophylaxis, 97.4% of antibiotics were given for more than one day. Conclusions: Unnecessary prophylactic antibiotic use is extremely high, and broad-spectrum prescribing is common among hospitals in Pakistan. There is an urgent need to work on the national action plan of Pakistan on antibiotic resistance to address this.
| Language | English |
|---|---|
| Pages | 285-293 |
| Number of pages | 9 |
| Journal | Expert Review of Anti-infective Therapy |
| Volume | 17 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 22 Feb 2019 |
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Keywords
- point prevalence survey
- antimicrobial prescribing
- antimicrobial resistance
- hospitals
- Pakistan
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A multicenter point prevalence survey of antibiotic use in Punjab, Pakistan : findings and implications. / Saleem, Zikria ; Hassali, Mohamed Azmi Ahmad; Versporten, Ann; Godman, Brian; Hashmi, Furqan Khurshid ; Goossens, Herman ; Saleem, Fahad.
In: Expert Review of Anti-infective Therapy, Vol. 17, No. 4, 22.02.2019, p. 285-293.Research output: Contribution to journal › Article
TY - JOUR
T1 - A multicenter point prevalence survey of antibiotic use in Punjab, Pakistan
T2 - Expert Review of Anti-infective Therapy
AU - Saleem, Zikria
AU - Hassali, Mohamed Azmi Ahmad
AU - Versporten, Ann
AU - Godman, Brian
AU - Hashmi, Furqan Khurshid
AU - Goossens, Herman
AU - Saleem, Fahad
PY - 2019/2/22
Y1 - 2019/2/22
N2 - Objectives: In line with the recent global action plan for antimicrobial resistance, this is the first time such a comprehensive antimicrobial point prevalence survey has been undertaken in Pakistan, the sixth most populous country. Methods: This point prevalence survey (PPS) was conducted in 13 hospitals among 7 different cities of Pakistan. The survey included all inpatients receiving an antibiotic on the day of PPS. A web-based application was used for data entry, validation, and reporting as designed by the University of Antwerp (www.global-pps.com). Results: Out of 1954 patients, 1516 (77.6%) were treated with antibiotics. The top three most reported indications for antibiotic use were prophylaxis for obstetrics or gynaecological indications (16.5%), gastrointestinal indications (12.6%) and lower respiratory tract infections (12.0%). The top three most commonly prescribed antibiotics were ceftriaxone (35.0%), metronidazole (16.0%) and ciprofloxacin (6.0%). Out of the total indications, 34.2% of antibiotics were prescribed for community-acquired infections (CAI), 5.9% for healthcare-associated infections (HAI), and 57.4% for either surgical or medical prophylaxis. Of the total use for surgical prophylaxis, 97.4% of antibiotics were given for more than one day. Conclusions: Unnecessary prophylactic antibiotic use is extremely high, and broad-spectrum prescribing is common among hospitals in Pakistan. There is an urgent need to work on the national action plan of Pakistan on antibiotic resistance to address this.
AB - Objectives: In line with the recent global action plan for antimicrobial resistance, this is the first time such a comprehensive antimicrobial point prevalence survey has been undertaken in Pakistan, the sixth most populous country. Methods: This point prevalence survey (PPS) was conducted in 13 hospitals among 7 different cities of Pakistan. The survey included all inpatients receiving an antibiotic on the day of PPS. A web-based application was used for data entry, validation, and reporting as designed by the University of Antwerp (www.global-pps.com). Results: Out of 1954 patients, 1516 (77.6%) were treated with antibiotics. The top three most reported indications for antibiotic use were prophylaxis for obstetrics or gynaecological indications (16.5%), gastrointestinal indications (12.6%) and lower respiratory tract infections (12.0%). The top three most commonly prescribed antibiotics were ceftriaxone (35.0%), metronidazole (16.0%) and ciprofloxacin (6.0%). Out of the total indications, 34.2% of antibiotics were prescribed for community-acquired infections (CAI), 5.9% for healthcare-associated infections (HAI), and 57.4% for either surgical or medical prophylaxis. Of the total use for surgical prophylaxis, 97.4% of antibiotics were given for more than one day. Conclusions: Unnecessary prophylactic antibiotic use is extremely high, and broad-spectrum prescribing is common among hospitals in Pakistan. There is an urgent need to work on the national action plan of Pakistan on antibiotic resistance to address this.
KW - point prevalence survey
KW - antimicrobial prescribing
KW - antimicrobial resistance
KW - hospitals
KW - Pakistan
UR - https://www.tandfonline.com/toc/ierz20/current
U2 - 10.1080/14787210.2019.1581063
DO - 10.1080/14787210.2019.1581063
M3 - Article
VL - 17
SP - 285
EP - 293
JO - Expert Review of Anti-infective Therapy
JF - Expert Review of Anti-infective Therapy
SN - 1478-7210
IS - 4
ER -