A monoclinic polymorph of chlorothiazide

Rowan K. H. Brydson; Alan R. Kennedy

doi:10.1107/S2056989024006078

A monoclinic polymorph of chlorothiazide

Rowan K. H. Brydson, Alan R. Kennedy

Pure And Applied Chemistry

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Abstract

A new polymorph of the diuretic chlorothiazide, 6-chloro-1,1-dioxo-2H-1,2,4-benzothiazine-7-sulfonamide, C7H6ClN3O4S2, is described. Crystallized from basic aqueous solution, this monoclinic polymorph is found to be less thermodynamically favoured than the known triclinic polymorph and to feature only N—H---O type intermolecular hydrogen bonds as opposed to the N—H---O and N—H---N type hydrogen bonds found in the P1 form.

Original language	English
Pages (from-to)	806-810
Number of pages	5
Journal	Acta Crystallographica Section E: Structure Reports
Volume	80
Issue number	Pt 7
Early online date	28 Jun 2024
DOIs	https://doi.org/10.1107/S2056989024006078
Publication status	Published - Jul 2024

Keywords

chlorothiazide
crystal structures
molecular structure

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title = "A monoclinic polymorph of chlorothiazide",

abstract = "A new polymorph of the diuretic chlorothiazide, 6-chloro-1,1-dioxo-2H-1,2,4-benzothiazine-7-sulfonamide, C7H6ClN3O4S2, is described. Crystallized from basic aqueous solution, this monoclinic polymorph is found to be less thermodynamically favoured than the known triclinic polymorph and to feature only N—H---O type intermolecular hydrogen bonds as opposed to the N—H---O and N—H---N type hydrogen bonds found in the P1 form.",

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author = "Brydson, {Rowan K. H.} and Kennedy, {Alan R.}",

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T1 - A monoclinic polymorph of chlorothiazide

AU - Brydson, Rowan K. H.

AU - Kennedy, Alan R.

PY - 2024/7

Y1 - 2024/7

N2 - A new polymorph of the diuretic chlorothiazide, 6-chloro-1,1-dioxo-2H-1,2,4-benzothiazine-7-sulfonamide, C7H6ClN3O4S2, is described. Crystallized from basic aqueous solution, this monoclinic polymorph is found to be less thermodynamically favoured than the known triclinic polymorph and to feature only N—H---O type intermolecular hydrogen bonds as opposed to the N—H---O and N—H---N type hydrogen bonds found in the P1 form.

AB - A new polymorph of the diuretic chlorothiazide, 6-chloro-1,1-dioxo-2H-1,2,4-benzothiazine-7-sulfonamide, C7H6ClN3O4S2, is described. Crystallized from basic aqueous solution, this monoclinic polymorph is found to be less thermodynamically favoured than the known triclinic polymorph and to feature only N—H---O type intermolecular hydrogen bonds as opposed to the N—H---O and N—H---N type hydrogen bonds found in the P1 form.

KW - chlorothiazide

KW - crystal structures

KW - molecular structure

UR - https://onlinelibrary.wiley.com/journal/s16005368

U2 - 10.1107/S2056989024006078

DO - 10.1107/S2056989024006078

M3 - Article

SN - 1600-5368

VL - 80

SP - 806

EP - 810

JO - Acta Crystallographica Section E: Structure Reports

JF - Acta Crystallographica Section E: Structure Reports

IS - Pt 7

ER -

A monoclinic polymorph of chlorothiazide

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Keywords

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