A modular synthesis of functionalised phenols enabled by controlled boron speciation

John J. Molloy, Robert P. Law, James W.B. Fyfe, Ciaran P. Seath, David J. Hirst, Allan J.B. Watson

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Abstract

A modular synthesis of functionalised biaryl phenols from two boronic acid derivatives has been developed via one-pot Suzuki-Miyaura cross-coupling, chemoselective control of boron solution speciation to generate a reactive boronic ester in situ, and oxidation. The utility of this method has been further demonstrated by application in the synthesis of drug molecules and components of organic electronics, as well as within iterative cross-coupling.
Original languageEnglish
Number of pages10
JournalOrganic and Biomolecular Chemistry
Early online date21 Jan 2015
DOIs
Publication statusE-pub ahead of print - 21 Jan 2015

Keywords

  • boronic acid
  • chemoselective control
  • boron
  • phenols

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  • Cite this

    Molloy, J. J., Law, R. P., Fyfe, J. W. B., Seath, C. P., Hirst, D. J., & Watson, A. J. B. (2015). A modular synthesis of functionalised phenols enabled by controlled boron speciation. Organic and Biomolecular Chemistry. https://doi.org/10.1039/C5OB00078E