A mild and efficient method for the one-pot monocarboxymethylation of primary amines

Timothy J. K. Gibbs, Michael Boomhoff, Nicholas C. O. Tomkinson

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6 Citations (Scopus)

Abstract

A mild and efficient method for the monocarboxymethylation of primary amines that takes place under aq. conditions at room temp. is described. Treatment of an aq. soln. of a variety of primary amines with two equiv. of glyoxylic acid leads to the N-formyl glycine derivs. Direct hydrolysis of the crude reaction soln. leads to the products of amine monocarboxymethylation in good to excellent yield.
Original languageUndefined/Unknown
Pages (from-to)1573-1576
Number of pages4
JournalSynlett
Issue number10
DOIs
Publication statusPublished - 2007

Keywords

  • one-pot monocarboxymethylation
  • primary amines

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