A mild and efficient method for the one-pot monocarboxymethylation of primary amines

Timothy J. K. Gibbs; Michael Boomhoff; Nicholas C. O. Tomkinson

doi:10.1055/s-2007-982531

A mild and efficient method for the one-pot monocarboxymethylation of primary amines

Timothy J. K. Gibbs, Michael Boomhoff, Nicholas C. O. Tomkinson

Pure And Applied Chemistry

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

A mild and efficient method for the monocarboxymethylation of primary amines that takes place under aq. conditions at room temp. is described. Treatment of an aq. soln. of a variety of primary amines with two equiv. of glyoxylic acid leads to the N-formyl glycine derivs. Direct hydrolysis of the crude reaction soln. leads to the products of amine monocarboxymethylation in good to excellent yield.

Original language	Undefined/Unknown
Pages (from-to)	1573-1576
Number of pages	4
Journal	Synlett
Issue number	10
DOIs	https://doi.org/10.1055/s-2007-982531
Publication status	Published - 2007

Keywords

one-pot monocarboxymethylation
primary amines

Access to Document

10.1055/s-2007-982531

Cite this

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title = "A mild and efficient method for the one-pot monocarboxymethylation of primary amines",

abstract = "A mild and efficient method for the monocarboxymethylation of primary amines that takes place under aq. conditions at room temp. is described. Treatment of an aq. soln. of a variety of primary amines with two equiv. of glyoxylic acid leads to the N-formyl glycine derivs. Direct hydrolysis of the crude reaction soln. leads to the products of amine monocarboxymethylation in good to excellent yield. ",

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AU - Gibbs, Timothy J. K.

AU - Boomhoff, Michael

AU - Tomkinson, Nicholas C. O.

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Y1 - 2007

N2 - A mild and efficient method for the monocarboxymethylation of primary amines that takes place under aq. conditions at room temp. is described. Treatment of an aq. soln. of a variety of primary amines with two equiv. of glyoxylic acid leads to the N-formyl glycine derivs. Direct hydrolysis of the crude reaction soln. leads to the products of amine monocarboxymethylation in good to excellent yield.

AB - A mild and efficient method for the monocarboxymethylation of primary amines that takes place under aq. conditions at room temp. is described. Treatment of an aq. soln. of a variety of primary amines with two equiv. of glyoxylic acid leads to the N-formyl glycine derivs. Direct hydrolysis of the crude reaction soln. leads to the products of amine monocarboxymethylation in good to excellent yield.

KW - one-pot monocarboxymethylation

KW - primary amines

U2 - 10.1055/s-2007-982531

DO - 10.1055/s-2007-982531

M3 - Article

SN - 0936-5214

SP - 1573

EP - 1576

JO - Synlett

JF - Synlett

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