A micropatterned hydrogel platform for chemical synthesis and biological analysis

M Zourob, J E Gough, R V Ulijn

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

A polymer hydrogel platform for peptide arrays compatible both with solid-phase peptide synthesis (SPPS) conditions and the aqueous environment essential for biological assays is demonstrated. Micropatterning followed by multiple-step peptide synthesis in situ is followed by proof-of-concept on-chip biological assays involving cells and enzymes (see Figure and cover).

LanguageEnglish
Pages655-659
Number of pages6
JournalAdvanced Materials
Volume18
Issue number5
DOIs
Publication statusPublished - 3 Mar 2006

Fingerprint

Hydrogel
Hydrogels
Peptides
Assays
Polymers
Enzymes

Keywords

  • micropatterned hydrogel platform
  • chemical synthesis
  • biological analysis
  • peptides
  • arrays
  • biosensors
  • cells
  • enzymes
  • hydrogels
  • micropatterning

Cite this

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A micropatterned hydrogel platform for chemical synthesis and biological analysis. / Zourob, M ; Gough, J E ; Ulijn, R V .

In: Advanced Materials, Vol. 18, No. 5, 03.03.2006, p. 655-659.

Research output: Contribution to journalArticle

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AU - Gough, J E

AU - Ulijn, R V

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KW - micropatterned hydrogel platform

KW - chemical synthesis

KW - biological analysis

KW - peptides

KW - arrays

KW - biosensors

KW - cells

KW - enzymes

KW - hydrogels

KW - micropatterning

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