A microfluidics tool for high-throughput, real-time multimodal imaging of nanoparticle-cell interactions

C. A. Cunha-Matos, O. M. Millington, A. W. Wark, M. Zagnoni

Research output: Chapter in Book/Report/Conference proceedingConference contribution book

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The increasing use of nanomaterials for biomedical applications has raised the need for efficient, robust and low-cost high-throughput assessment of nanotoxicity and cell-nanoparticle interactions. Microfluidics provides the tools for high-throughput single-cell functional monitoring, while gold nanorods have unique potential for intracellular tracking and can simultaneously be used as drug carriers. Presented here is a miniaturised platform that integrates these features with a multimodal approach to cell imaging. A microfluidic device allows for trapping of an array of singlecells, followed by the controlled delivery of nanoparticles into the cell array and subsequent real-time multimodal imaging of cellular interactions with functionalised nanoparticles. This system has been successfully used to assess cellnanoparticle interactions at the single-cell level.
Original languageEnglish
Title of host publication4th European Conference on Microfluidics, Limerick, 10-12 December 2014
EditorsStéphane Colin, Gian Luca Morini, Jürgen J. Brandner
Place of PublicationParis
Number of pages5
Publication statusPublished - Dec 2014
EventMicrofluidics 2014 - Castletroy Park Hotel, Limerick, Ireland
Duration: 10 Dec 201412 Dec 2014


ConferenceMicrofluidics 2014
Internet address


  • microfluidics
  • nanoparticle-cell interactions
  • real-time multimodal imaging
  • biomedical applications
  • nanomaterials
  • nanotoxicity
  • cell imaging


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