Projects per year
Abstract
The increasing use of nanomaterials for biomedical applications has raised the need for efficient, robust and low-cost high-throughput assessment of nanotoxicity and cell-nanoparticle interactions. Microfluidics provides the tools for high-throughput single-cell functional monitoring, while gold nanorods have unique potential for intracellular tracking and can simultaneously be used as drug carriers. Presented here is a miniaturised platform that integrates these features with a multimodal approach to cell imaging. A microfluidic device allows for trapping of an array of singlecells, followed by the controlled delivery of nanoparticles into the cell array and subsequent real-time multimodal imaging of cellular interactions with functionalised nanoparticles. This system has been successfully used to assess cellnanoparticle interactions at the single-cell level.
Original language | English |
---|---|
Title of host publication | 4th European Conference on Microfluidics, Limerick, 10-12 December 2014 |
Editors | Stéphane Colin, Gian Luca Morini, Jürgen J. Brandner |
Place of Publication | Paris |
Number of pages | 5 |
Publication status | Published - Dec 2014 |
Event | Microfluidics 2014 - Castletroy Park Hotel, Limerick, Ireland Duration: 10 Dec 2014 → 12 Dec 2014 http://www.ul.ie/news-centre/events/4th-european-conference-on-microfluidics |
Conference
Conference | Microfluidics 2014 |
---|---|
Country/Territory | Ireland |
City | Limerick |
Period | 10/12/14 → 12/12/14 |
Internet address |
Keywords
- microfluidics
- nanoparticle-cell interactions
- real-time multimodal imaging
- biomedical applications
- nanomaterials
- nanotoxicity
- cell imaging
Fingerprint
Dive into the research topics of 'A microfluidics tool for high-throughput, real-time multimodal imaging of nanoparticle-cell interactions'. Together they form a unique fingerprint.-
BTG- Researcher-led Project
Zagnoni, M. (Principal Investigator) & Bushell, T. (Principal Investigator)
5/09/11 → …
Project: Internally funded project
-
Medical Devices Doctoral Training Centre Renewal
Connolly, P. (Principal Investigator)
EPSRC (Engineering and Physical Sciences Research Council)
1/10/08 → 31/03/18
Project: Research - Studentship