A microfluidics tool for high-throughput, real-time multimodal imaging of nanoparticle-cell interactions

C. A. Cunha-Matos, O. M. Millington, A. W. Wark, M. Zagnoni

Research output: Chapter in Book/Report/Conference proceedingConference contribution book

23 Downloads (Pure)

Abstract

The increasing use of nanomaterials for biomedical applications has raised the need for efficient, robust and low-cost high-throughput assessment of nanotoxicity and cell-nanoparticle interactions. Microfluidics provides the tools for high-throughput single-cell functional monitoring, while gold nanorods have unique potential for intracellular tracking and can simultaneously be used as drug carriers. Presented here is a miniaturised platform that integrates these features with a multimodal approach to cell imaging. A microfluidic device allows for trapping of an array of singlecells, followed by the controlled delivery of nanoparticles into the cell array and subsequent real-time multimodal imaging of cellular interactions with functionalised nanoparticles. This system has been successfully used to assess cellnanoparticle interactions at the single-cell level.
Original languageEnglish
Title of host publication4th European Conference on Microfluidics, Limerick, 10-12 December 2014
EditorsStéphane Colin, Gian Luca Morini, Jürgen J. Brandner
Place of PublicationParis
Number of pages5
Publication statusPublished - Dec 2014
EventMicrofluidics 2014 - Castletroy Park Hotel, Limerick, Ireland
Duration: 10 Dec 201412 Dec 2014
http://www.ul.ie/news-centre/events/4th-european-conference-on-microfluidics

Conference

ConferenceMicrofluidics 2014
CountryIreland
CityLimerick
Period10/12/1412/12/14
Internet address

    Fingerprint

Keywords

  • microfluidics
  • nanoparticle-cell interactions
  • real-time multimodal imaging
  • biomedical applications
  • nanomaterials
  • nanotoxicity
  • cell imaging

Cite this

Cunha-Matos, C. A., Millington, O. M., Wark, A. W., & Zagnoni, M. (2014). A microfluidics tool for high-throughput, real-time multimodal imaging of nanoparticle-cell interactions. In S. Colin, G. L. Morini, & J. J. Brandner (Eds.), 4th European Conference on Microfluidics, Limerick, 10-12 December 2014 Paris.