A microfluidics platform for human tau mutation neurons

Emma Torrance; Graham Robertson; Selina Wray; John Hardy; Trevor Bushell; Michele Zagnoni

A microfluidics platform for human tau mutation neurons

Emma Torrance, Graham Robertson, Selina Wray, John Hardy, Trevor Bushell, Michele Zagnoni

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution book

Abstract

This paper reports a microfluidic approach for assessing network formation in human induced pluripotent stem cell (iPSC)-derived neurons. For the first time, we show the ability of iPSC-derived neurons to form functional synaptically driven networks within a controlled microfluidic environment, thus providing an in vitro stem cell based model for studying dementia.

Original language	English
Title of host publication	MicroTAS 2014
Place of Publication	San Diego, CA.
Pages	898-890
Number of pages	3
ISBN (Electronic)	9780979806476
Publication status	Published - 2014
Event	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2014) - Texas, San Antonio, United States Duration: 26 Oct 2014 → 30 Oct 2014

Conference

Conference	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2014)
Country/Territory	United States
City	San Antonio
Period	26/10/14 → 30/10/14

Keywords

induced pluripotent stem cell derived neurons
frontotemporal dementia
tau mutation

Cite this

@inproceedings{c79a21accf9f4435aa1b39ff035c0794,

title = "A microfluidics platform for human tau mutation neurons",

abstract = "This paper reports a microfluidic approach for assessing network formation in human induced pluripotent stem cell (iPSC)-derived neurons. For the first time, we show the ability of iPSC-derived neurons to form functional synaptically driven networks within a controlled microfluidic environment, thus providing an in vitro stem cell based model for studying dementia.",

keywords = "induced pluripotent stem cell derived neurons, frontotemporal dementia, tau mutation",

author = "Emma Torrance and Graham Robertson and Selina Wray and John Hardy and Trevor Bushell and Michele Zagnoni",

year = "2014",

language = "English",

pages = "898--890",

booktitle = "MicroTAS 2014",

note = "18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2014) ; Conference date: 26-10-2014 Through 30-10-2014",

}

TY - GEN

T1 - A microfluidics platform for human tau mutation neurons

AU - Torrance, Emma

AU - Robertson, Graham

AU - Wray, Selina

AU - Hardy, John

AU - Bushell, Trevor

AU - Zagnoni, Michele

PY - 2014

Y1 - 2014

N2 - This paper reports a microfluidic approach for assessing network formation in human induced pluripotent stem cell (iPSC)-derived neurons. For the first time, we show the ability of iPSC-derived neurons to form functional synaptically driven networks within a controlled microfluidic environment, thus providing an in vitro stem cell based model for studying dementia.

AB - This paper reports a microfluidic approach for assessing network formation in human induced pluripotent stem cell (iPSC)-derived neurons. For the first time, we show the ability of iPSC-derived neurons to form functional synaptically driven networks within a controlled microfluidic environment, thus providing an in vitro stem cell based model for studying dementia.

KW - induced pluripotent stem cell derived neurons

KW - frontotemporal dementia

KW - tau mutation

UR - http://www.rsc.org/images/loc/2014/PDFs/Papers/294_0336.pdf

UR - http://www.microtasconferences.org/microtas2014/

M3 - Conference contribution book

SP - 898

EP - 890

BT - MicroTAS 2014

CY - San Diego, CA.

T2 - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2014)

Y2 - 26 October 2014 through 30 October 2014

ER -

A microfluidics platform for human tau mutation neurons

Abstract

Conference

Keywords

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Cite this