A microfluidics platform for human tau mutation neurons

Emma Torrance, Graham Robertson, Selina Wray, John Hardy, Trevor Bushell, Michele Zagnoni

Research output: Chapter in Book/Report/Conference proceedingConference contribution book

1 Citation (Scopus)

Abstract

This paper reports a microfluidic approach for assessing network formation in human induced pluripotent stem cell (iPSC)-derived neurons. For the first time, we show the ability of iPSC-derived neurons to form functional synaptically driven networks within a controlled microfluidic environment, thus providing an in vitro stem cell based model for studying dementia.
Original languageEnglish
Title of host publicationMicroTAS 2014
Place of PublicationSan Diego, CA.
Pages898-890
Number of pages3
ISBN (Electronic)9780979806476
Publication statusPublished - 2014
Event18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2014) - Texas, San Antonio, United States
Duration: 26 Oct 201430 Oct 2014

Conference

Conference18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2014)
CountryUnited States
CitySan Antonio
Period26/10/1430/10/14

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Keywords

  • induced pluripotent stem cell derived neurons
  • frontotemporal dementia
  • tau mutation

Cite this

Torrance, E., Robertson, G., Wray, S., Hardy, J., Bushell, T., & Zagnoni, M. (2014). A microfluidics platform for human tau mutation neurons. In MicroTAS 2014 (pp. 898-890). San Diego, CA..