Abstract
This paper reports a microfluidic approach for assessing network formation in human induced pluripotent stem cell (iPSC)-derived neurons. For the first time, we show the ability of iPSC-derived neurons to form functional synaptically driven networks within a controlled microfluidic environment, thus providing an in vitro stem cell based model for studying dementia.
Original language | English |
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Title of host publication | MicroTAS 2014 |
Place of Publication | San Diego, CA. |
Pages | 898-890 |
Number of pages | 3 |
ISBN (Electronic) | 9780979806476 |
Publication status | Published - 2014 |
Event | 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2014) - Texas, San Antonio, United States Duration: 26 Oct 2014 → 30 Oct 2014 |
Conference
Conference | 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2014) |
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Country/Territory | United States |
City | San Antonio |
Period | 26/10/14 → 30/10/14 |
Keywords
- induced pluripotent stem cell derived neurons
- frontotemporal dementia
- tau mutation