A longitudinal study of leptin and appetite, resting energy expenditure and body fat mass in weight-stable cancer patients

Roma Maguire, Donald C McMillan, A Michael Wallace, Colin McArdle

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Leptin and its relationship with energy metabolism in male weight-stable patients with colorectal liver metastases (n=14) was assessed at baseline and after 6 weeks. At baseline, median leptin concentration was 5.9 microg/l and the median percentage fat mass was 32.1%. Circulating leptin concentrations were correlated with measured percentage fat mass at baseline (r(s)=0.519, P=0.040) and with the changes after 6 weeks (r(s)=0.611, P=0.027) but not with insulin, cortisol, C-reactive protein, appetite or resting energy expenditure. Therefore, it would appear that leptin concentrations reflect changes in fat mass in male weight-stable patients with cancer and their role in the regulation of energy metabolism appears more complex than previously proposed.

LanguageEnglish
Pages174-177
Number of pages4
JournalCytokine
Volume20
Issue number4
Publication statusPublished - 24 Nov 2002
Externally publishedYes

Fingerprint

Appetite
Leptin
Energy Metabolism
Longitudinal Studies
Adipose Tissue
Fats
Weights and Measures
Neoplasms
Liver
C-Reactive Protein
Hydrocortisone
Insulin
Neoplasm Metastasis

Keywords

  • adenocarcinoma
  • adipose tissue
  • colorectal neoplasms

Cite this

Maguire, Roma ; McMillan, Donald C ; Wallace, A Michael ; McArdle, Colin. / A longitudinal study of leptin and appetite, resting energy expenditure and body fat mass in weight-stable cancer patients. In: Cytokine. 2002 ; Vol. 20, No. 4. pp. 174-177.
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A longitudinal study of leptin and appetite, resting energy expenditure and body fat mass in weight-stable cancer patients. / Maguire, Roma; McMillan, Donald C; Wallace, A Michael; McArdle, Colin.

In: Cytokine, Vol. 20, No. 4, 24.11.2002, p. 174-177.

Research output: Contribution to journalArticle

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AU - McMillan, Donald C

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AU - McArdle, Colin

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AB - Leptin and its relationship with energy metabolism in male weight-stable patients with colorectal liver metastases (n=14) was assessed at baseline and after 6 weeks. At baseline, median leptin concentration was 5.9 microg/l and the median percentage fat mass was 32.1%. Circulating leptin concentrations were correlated with measured percentage fat mass at baseline (r(s)=0.519, P=0.040) and with the changes after 6 weeks (r(s)=0.611, P=0.027) but not with insulin, cortisol, C-reactive protein, appetite or resting energy expenditure. Therefore, it would appear that leptin concentrations reflect changes in fat mass in male weight-stable patients with cancer and their role in the regulation of energy metabolism appears more complex than previously proposed.

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