A local drug delivery technology to prevent implant infections

Justine Fraser; Michelle MacLean; Christopher McCormick

A local drug delivery technology to prevent implant infections

Justine Fraser, Michelle MacLean, Christopher McCormick

Research output: Contribution to conference › Poster › peer-review

Abstract

Medical implant associated infection is an ongoing problem, which can be particularly problematic when infection pathogenesis involves formation of bacterial biofilms. Biodegradable polymer drug delivery technology may be of use in some devices as a means of delivering a high local dose of antimicrobial drug. In this study the broad-spectrum antibiotic rifampicin was formulated with the polymer PLGA (Poly(D,L-lactic-co-glycolic acid (65:35)) and the in vitro drug release and activity analysed.

Original language	English
Publication status	Published - 6 Sept 2018
Event	BioMedEng18 - Imperial College, London, United Kingdom Duration: 6 Sept 2018 → 7 Sept 2018 https://www.biomedeng18.com/

Conference

Conference	BioMedEng18
Abbreviated title	BioMedEng
Country/Territory	United Kingdom
City	London
Period	6/09/18 → 7/09/18
Internet address	https://www.biomedeng18.com/

Keywords

medical implant
infection
bacterial biofilms
drug delivery technology

Cite this

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title = "A local drug delivery technology to prevent implant infections",

abstract = "Medical implant associated infection is an ongoing problem, which can be particularly problematic when infection pathogenesis involves formation of bacterial biofilms. Biodegradable polymer drug delivery technology may be of use in some devices as a means of delivering a high local dose of antimicrobial drug. In this study the broad-spectrum antibiotic rifampicin was formulated with the polymer PLGA (Poly(D,L-lactic-co-glycolic acid (65:35)) and the in vitro drug release and activity analysed.",

keywords = "medical implant, infection, bacterial biofilms, drug delivery technology",

author = "Justine Fraser and Michelle MacLean and Christopher McCormick",

year = "2018",

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language = "English",

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TY - CONF

T1 - A local drug delivery technology to prevent implant infections

AU - Fraser, Justine

AU - MacLean, Michelle

AU - McCormick, Christopher

PY - 2018/9/6

Y1 - 2018/9/6

N2 - Medical implant associated infection is an ongoing problem, which can be particularly problematic when infection pathogenesis involves formation of bacterial biofilms. Biodegradable polymer drug delivery technology may be of use in some devices as a means of delivering a high local dose of antimicrobial drug. In this study the broad-spectrum antibiotic rifampicin was formulated with the polymer PLGA (Poly(D,L-lactic-co-glycolic acid (65:35)) and the in vitro drug release and activity analysed.

AB - Medical implant associated infection is an ongoing problem, which can be particularly problematic when infection pathogenesis involves formation of bacterial biofilms. Biodegradable polymer drug delivery technology may be of use in some devices as a means of delivering a high local dose of antimicrobial drug. In this study the broad-spectrum antibiotic rifampicin was formulated with the polymer PLGA (Poly(D,L-lactic-co-glycolic acid (65:35)) and the in vitro drug release and activity analysed.

KW - medical implant

KW - infection

KW - bacterial biofilms

KW - drug delivery technology

UR - https://www.biomedeng18.com/

M3 - Poster

T2 - BioMedEng18

Y2 - 6 September 2018 through 7 September 2018

ER -

A local drug delivery technology to prevent implant infections

Abstract

Conference

Keywords

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