A local drug delivery technology to prevent implant infections

Research output: Contribution to conferencePoster

Abstract

Medical implant associated infection is an ongoing problem, which can be particularly problematic when infection pathogenesis involves formation of bacterial biofilms. Biodegradable polymer drug delivery technology may be of use in some devices as a means of delivering a high local dose of antimicrobial drug. In this study the broad-spectrum antibiotic rifampicin was formulated with the polymer PLGA (Poly(D,L-lactic-co-glycolic acid (65:35)) and the in vitro drug release and activity analysed.

Conference

ConferenceBioMedEng18
Abbreviated titleBioMedEng
CountryUnited Kingdom
CityLondon
Period6/09/187/09/18
Internet address

Fingerprint

Biodegradable polymers
Biofilms
Antibiotics
Drug delivery
Acids
Polymers
Milk

Keywords

  • medical implant
  • infection
  • bacterial biofilms
  • drug delivery technology

Cite this

Fraser, J., MacLean, M., & McCormick, C. (2018). A local drug delivery technology to prevent implant infections. Poster session presented at BioMedEng18, London, United Kingdom.
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title = "A local drug delivery technology to prevent implant infections",
abstract = "Medical implant associated infection is an ongoing problem, which can be particularly problematic when infection pathogenesis involves formation of bacterial biofilms. Biodegradable polymer drug delivery technology may be of use in some devices as a means of delivering a high local dose of antimicrobial drug. In this study the broad-spectrum antibiotic rifampicin was formulated with the polymer PLGA (Poly(D,L-lactic-co-glycolic acid (65:35)) and the in vitro drug release and activity analysed.",
keywords = "medical implant, infection, bacterial biofilms, drug delivery technology",
author = "Justine Fraser and Michelle MacLean and Christopher McCormick",
year = "2018",
month = "9",
day = "6",
language = "English",
note = "BioMedEng18, BioMedEng ; Conference date: 06-09-2018 Through 07-09-2018",
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Fraser, J, MacLean, M & McCormick, C 2018, 'A local drug delivery technology to prevent implant infections' BioMedEng18, London, United Kingdom, 6/09/18 - 7/09/18, .

A local drug delivery technology to prevent implant infections. / Fraser, Justine; MacLean, Michelle; McCormick, Christopher.

2018. Poster session presented at BioMedEng18, London, United Kingdom.

Research output: Contribution to conferencePoster

TY - CONF

T1 - A local drug delivery technology to prevent implant infections

AU - Fraser, Justine

AU - MacLean, Michelle

AU - McCormick, Christopher

PY - 2018/9/6

Y1 - 2018/9/6

N2 - Medical implant associated infection is an ongoing problem, which can be particularly problematic when infection pathogenesis involves formation of bacterial biofilms. Biodegradable polymer drug delivery technology may be of use in some devices as a means of delivering a high local dose of antimicrobial drug. In this study the broad-spectrum antibiotic rifampicin was formulated with the polymer PLGA (Poly(D,L-lactic-co-glycolic acid (65:35)) and the in vitro drug release and activity analysed.

AB - Medical implant associated infection is an ongoing problem, which can be particularly problematic when infection pathogenesis involves formation of bacterial biofilms. Biodegradable polymer drug delivery technology may be of use in some devices as a means of delivering a high local dose of antimicrobial drug. In this study the broad-spectrum antibiotic rifampicin was formulated with the polymer PLGA (Poly(D,L-lactic-co-glycolic acid (65:35)) and the in vitro drug release and activity analysed.

KW - medical implant

KW - infection

KW - bacterial biofilms

KW - drug delivery technology

UR - https://www.biomedeng18.com/

M3 - Poster

ER -

Fraser J, MacLean M, McCormick C. A local drug delivery technology to prevent implant infections. 2018. Poster session presented at BioMedEng18, London, United Kingdom.