### Abstract

We present a general theoretical framework to model the partitioning behavior of solutes in phase-separated solutions. Our approach makes
use of the McMillan-Mayer solution theory to construct a Gibbs free
energy model of the solution. This approach has the following desirable
features: (i) the molecular structures of the solute species as well
as their interactions are explicit inputs, and, therefore, the application
of the theory is not restricted to a particular system, and (ii)
the accuracy of the theory can be systematically improved, since
the various approximations involved in constructing the solution
Gibbs free energy model are clearly delineated. We illustrate the
practical implementation of the theoretical framework by examining
three cases. First, the theory is utilized in the context of a truncated
virial expansion in solution concentration to derive an expression
for the solute partition coefficient. Second, the theory is utilized
to model protein partitioning in two-phase aqueous surfactant solutions.
Third, the theory is utilized to qualitatively predict the partitioning
behavior of proteins in a model two-phase aqueous polymer solution,
accounting explicitly for the semidilute nature of the concentrated
polymer solution phase, We find that the theory captures many of
the salient experimental trends observed in protein partitioning
in two-phase aqueous polymer solutions.

Original language | English |
---|---|

Pages (from-to) | 3032-3043 |

Number of pages | 12 |

Journal | Industrial and Engineering Chemistry Research |

Volume | 35 |

Issue number | 9 |

DOIs | |

Publication status | Published - 1996 |

### Keywords

- aqueous polymer systems
- integral-equation theory
- chain molecules
- 2-phase systems
- micellar solutions
- hard-spheres
- thermodynamics
- biomaterials
- proteins
- dilute

## Fingerprint Dive into the research topics of 'A liquid-state theory approach to modeling solute partitioning in phase-separated solutions'. Together they form a unique fingerprint.

## Cite this

Lue, L., & Blankschtein, D. (1996). A liquid-state theory approach to modeling solute partitioning in phase-separated solutions.

*Industrial and Engineering Chemistry Research*,*35*(9), 3032-3043. https://doi.org/10.1021/ie950756k