A large-scale protein-function database

Rolf Apweiler, Richard Armstrong, Amos Bairoch, Athel Cornish-Bowden, Peter J. Halling, Jan-Hendrik S. Hofmeyr, Carsten Kettner, Thomas S. Leyh, Johann Rohwer, Dietmar Schomburg, Christoph Steinbeck, Keith Tipton

Research output: Contribution to journalLetter

11 Citations (Scopus)

Abstract

The rate at which data is acquired frequently outstrips the capacity of the human mind to house it. Instead, we mine it. The ability to electronically cull the majority of mankind's knowledge of the functioning of a particular biomolecule at the push of a button would be an acutely effective, efficient research tool. Consider the benefits of crossing such information against single nucleotide polymorphism databases to identify the biochemical lesions associated with disease-linked mutations or associate the functional consequences of mutations with changes in the structures housed in the Protein Data Bank. Additionally, as systems biologists strive to integrate large swaths of metabolism, ready access to initial-rate equilibria and regulatory data will prove immensely useful. Perhaps the greatest value of such a database lies in the myriad ways in which it would integrate into the daily activities of individuals, worldwide. One cannot help but wonder what fraction of the protein-function literature is obscured or even lost to the researcher by imprecise search engines and retrieval strategies.
LanguageEnglish
Pages785-785
Number of pages1
JournalNature Chemical Biology
Volume6
Issue number11
DOIs
Publication statusPublished - Nov 2010

Fingerprint

Protein Databases
Databases
Search Engine
Mutation
Single Nucleotide Polymorphism
Proteins
Research Personnel
Research

Keywords

  • protein-function database
  • Information retrieval

Cite this

Apweiler, R., Armstrong, R., Bairoch, A., Cornish-Bowden, A., Halling, P. J., Hofmeyr, J-H. S., ... Tipton, K. (2010). A large-scale protein-function database. Nature Chemical Biology, 6(11), 785-785. https://doi.org/10.1038/nchembio.460
Apweiler, Rolf ; Armstrong, Richard ; Bairoch, Amos ; Cornish-Bowden, Athel ; Halling, Peter J. ; Hofmeyr, Jan-Hendrik S. ; Kettner, Carsten ; Leyh, Thomas S. ; Rohwer, Johann ; Schomburg, Dietmar ; Steinbeck, Christoph ; Tipton, Keith. / A large-scale protein-function database. In: Nature Chemical Biology. 2010 ; Vol. 6, No. 11. pp. 785-785.
@article{686f4dc29e7449979801f7657a38f79a,
title = "A large-scale protein-function database",
abstract = "The rate at which data is acquired frequently outstrips the capacity of the human mind to house it. Instead, we mine it. The ability to electronically cull the majority of mankind's knowledge of the functioning of a particular biomolecule at the push of a button would be an acutely effective, efficient research tool. Consider the benefits of crossing such information against single nucleotide polymorphism databases to identify the biochemical lesions associated with disease-linked mutations or associate the functional consequences of mutations with changes in the structures housed in the Protein Data Bank. Additionally, as systems biologists strive to integrate large swaths of metabolism, ready access to initial-rate equilibria and regulatory data will prove immensely useful. Perhaps the greatest value of such a database lies in the myriad ways in which it would integrate into the daily activities of individuals, worldwide. One cannot help but wonder what fraction of the protein-function literature is obscured or even lost to the researcher by imprecise search engines and retrieval strategies.",
keywords = "protein-function database , Information retrieval",
author = "Rolf Apweiler and Richard Armstrong and Amos Bairoch and Athel Cornish-Bowden and Halling, {Peter J.} and Hofmeyr, {Jan-Hendrik S.} and Carsten Kettner and Leyh, {Thomas S.} and Johann Rohwer and Dietmar Schomburg and Christoph Steinbeck and Keith Tipton",
year = "2010",
month = "11",
doi = "10.1038/nchembio.460",
language = "English",
volume = "6",
pages = "785--785",
journal = "Nature Chemical Biology",
issn = "1552-4450",
number = "11",

}

Apweiler, R, Armstrong, R, Bairoch, A, Cornish-Bowden, A, Halling, PJ, Hofmeyr, J-HS, Kettner, C, Leyh, TS, Rohwer, J, Schomburg, D, Steinbeck, C & Tipton, K 2010, 'A large-scale protein-function database' Nature Chemical Biology, vol. 6, no. 11, pp. 785-785. https://doi.org/10.1038/nchembio.460

A large-scale protein-function database. / Apweiler, Rolf; Armstrong, Richard; Bairoch, Amos; Cornish-Bowden, Athel; Halling, Peter J.; Hofmeyr, Jan-Hendrik S.; Kettner, Carsten; Leyh, Thomas S.; Rohwer, Johann; Schomburg, Dietmar; Steinbeck, Christoph; Tipton, Keith.

In: Nature Chemical Biology, Vol. 6, No. 11, 11.2010, p. 785-785.

Research output: Contribution to journalLetter

TY - JOUR

T1 - A large-scale protein-function database

AU - Apweiler, Rolf

AU - Armstrong, Richard

AU - Bairoch, Amos

AU - Cornish-Bowden, Athel

AU - Halling, Peter J.

AU - Hofmeyr, Jan-Hendrik S.

AU - Kettner, Carsten

AU - Leyh, Thomas S.

AU - Rohwer, Johann

AU - Schomburg, Dietmar

AU - Steinbeck, Christoph

AU - Tipton, Keith

PY - 2010/11

Y1 - 2010/11

N2 - The rate at which data is acquired frequently outstrips the capacity of the human mind to house it. Instead, we mine it. The ability to electronically cull the majority of mankind's knowledge of the functioning of a particular biomolecule at the push of a button would be an acutely effective, efficient research tool. Consider the benefits of crossing such information against single nucleotide polymorphism databases to identify the biochemical lesions associated with disease-linked mutations or associate the functional consequences of mutations with changes in the structures housed in the Protein Data Bank. Additionally, as systems biologists strive to integrate large swaths of metabolism, ready access to initial-rate equilibria and regulatory data will prove immensely useful. Perhaps the greatest value of such a database lies in the myriad ways in which it would integrate into the daily activities of individuals, worldwide. One cannot help but wonder what fraction of the protein-function literature is obscured or even lost to the researcher by imprecise search engines and retrieval strategies.

AB - The rate at which data is acquired frequently outstrips the capacity of the human mind to house it. Instead, we mine it. The ability to electronically cull the majority of mankind's knowledge of the functioning of a particular biomolecule at the push of a button would be an acutely effective, efficient research tool. Consider the benefits of crossing such information against single nucleotide polymorphism databases to identify the biochemical lesions associated with disease-linked mutations or associate the functional consequences of mutations with changes in the structures housed in the Protein Data Bank. Additionally, as systems biologists strive to integrate large swaths of metabolism, ready access to initial-rate equilibria and regulatory data will prove immensely useful. Perhaps the greatest value of such a database lies in the myriad ways in which it would integrate into the daily activities of individuals, worldwide. One cannot help but wonder what fraction of the protein-function literature is obscured or even lost to the researcher by imprecise search engines and retrieval strategies.

KW - protein-function database

KW - Information retrieval

UR - http://www.scopus.com/inward/record.url?scp=77958190048&partnerID=8YFLogxK

U2 - 10.1038/nchembio.460

DO - 10.1038/nchembio.460

M3 - Letter

VL - 6

SP - 785

EP - 785

JO - Nature Chemical Biology

T2 - Nature Chemical Biology

JF - Nature Chemical Biology

SN - 1552-4450

IS - 11

ER -

Apweiler R, Armstrong R, Bairoch A, Cornish-Bowden A, Halling PJ, Hofmeyr J-HS et al. A large-scale protein-function database. Nature Chemical Biology. 2010 Nov;6(11):785-785. https://doi.org/10.1038/nchembio.460