TY - JOUR
T1 - A large-scale protein-function database
AU - Apweiler, Rolf
AU - Armstrong, Richard
AU - Bairoch, Amos
AU - Cornish-Bowden, Athel
AU - Halling, Peter J.
AU - Hofmeyr, Jan-Hendrik S.
AU - Kettner, Carsten
AU - Leyh, Thomas S.
AU - Rohwer, Johann
AU - Schomburg, Dietmar
AU - Steinbeck, Christoph
AU - Tipton, Keith
PY - 2010/11
Y1 - 2010/11
N2 - The rate at which data is acquired frequently outstrips the capacity of the human mind to house it. Instead, we mine it. The ability to electronically cull the majority of mankind's knowledge of the functioning of a particular biomolecule at the push of a button would be an acutely effective, efficient research tool. Consider the benefits of crossing such information against single nucleotide polymorphism databases to identify the biochemical lesions associated with disease-linked mutations or associate the functional consequences of mutations with changes in the structures housed in the Protein Data Bank. Additionally, as systems biologists strive to integrate large swaths of metabolism, ready access to initial-rate equilibria and regulatory data will prove immensely useful. Perhaps the greatest value of such a database lies in the myriad ways in which it would integrate into the daily activities of individuals, worldwide. One cannot help but wonder what fraction of the protein-function literature is obscured or even lost to the researcher by imprecise search engines and retrieval strategies.
AB - The rate at which data is acquired frequently outstrips the capacity of the human mind to house it. Instead, we mine it. The ability to electronically cull the majority of mankind's knowledge of the functioning of a particular biomolecule at the push of a button would be an acutely effective, efficient research tool. Consider the benefits of crossing such information against single nucleotide polymorphism databases to identify the biochemical lesions associated with disease-linked mutations or associate the functional consequences of mutations with changes in the structures housed in the Protein Data Bank. Additionally, as systems biologists strive to integrate large swaths of metabolism, ready access to initial-rate equilibria and regulatory data will prove immensely useful. Perhaps the greatest value of such a database lies in the myriad ways in which it would integrate into the daily activities of individuals, worldwide. One cannot help but wonder what fraction of the protein-function literature is obscured or even lost to the researcher by imprecise search engines and retrieval strategies.
KW - protein-function database
KW - Information retrieval
UR - http://www.scopus.com/inward/record.url?scp=77958190048&partnerID=8YFLogxK
U2 - 10.1038/nchembio.460
DO - 10.1038/nchembio.460
M3 - Letter
VL - 6
SP - 785
EP - 785
JO - Nature Chemical Biology
JF - Nature Chemical Biology
SN - 1552-4450
IS - 11
ER -